PCOS Clinical Trial
Official title:
Clomiphene Citrate Plus N-acetyl Cysteine Versus Clomiphene Citrate for Induction of Ovulation in Women With Newly Diagnosed Polycystic Ovary Syndrome: a Randomized Double-blind Controlled Trial
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting
approximately 6-10% of women of reproductive age. Anovulation, infertility and
hyperandrogenism often co-exist with hyperinsulinaemia and insulin resistance .
Clomiphene citrate remains the standard drug for induction or augmentation of ovulation.
However, it is not equally effective in all situations, and therefore it may require
additional expensive drugs such as N-acetyl cysteine, as an antioxidant, has been suggested
as an adjuvant in clomiphene-resistant cases .NAC may also improve the circulating level of
insulin and insulin sensitivity in hyperinsulinaemic women with PCOS, and may be useful for
the treatment of insulin resistance by ameliorating the homocysteine and lipid profile in
PCOS .
NAC has been used effectively as an adjuvant to clomiphene citrate (CC) for ovulation
induction in CC-resistant women with PCOS .
Because it is an insulin sensitizer, NAC was proposed as an adjuvant to clomiphene citrate
for ovulation induction in patients with polycystic ovary syndrome who are resistant to
clomiphene citrate. Encouraging results in those patients stimulated us to investigate
whether adding NAC to the standard treatment with CC results in a higher ovulation rate,
higher pregnancy rate, and less CC resistance in women with newly diagnosed polycystic ovary
syndrome using a randomized, double-blind, controlled study.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06101147 -
Effect of Vitamin D Supplementation on Testosterone Level in Women With Polycystic Ovary Syndrome
|
Phase 2 | |
| Completed |
NCT02037672 -
PDE-4 Inhibitor Roflumilast and Polycystic Ovary Syndrome
|
Phase 4 | |
| Completed |
NCT01833949 -
Unilateral Laparoscopic Diathermy Adjusted to Ovarian Volume
|
N/A | |
| Completed |
NCT03608813 -
Myo-inositol, D-chiro-inositol and Glucomannan in PCOS
|
||
| Not yet recruiting |
NCT05298657 -
The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment
|
||
| Completed |
NCT05951309 -
Myoinositol Treatment and Asprosin Levels in PCOS
|
N/A | |
| Enrolling by invitation |
NCT04485403 -
The Effect of Ibuprofen on Women With PCOS.
|
Phase 2 | |
| Not yet recruiting |
NCT03978013 -
Pomegranate Juice Effect on Oxidative Stress in Infertile Women During IVF Treatment
|
N/A | |
| Recruiting |
NCT03767569 -
Myo-inositol as Pretreatment in Hyperandrogenic PCOS Patients
|
Phase 3 | |
| Completed |
NCT05843955 -
Non-alcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome
|
||
| Recruiting |
NCT05971849 -
Dampening the Reproductive Axis With Continuous Kisspeptin
|
Phase 1 | |
| Recruiting |
NCT04597099 -
Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion
|
Early Phase 1 | |
| Active, not recruiting |
NCT05206448 -
Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With Anovulation
|
Phase 4 | |
| Recruiting |
NCT02358421 -
Prediction of High Ovarian Response After Assisted Reproductive Techniques
|
N/A | |
| Completed |
NCT04113889 -
Effects of Triple Drug Cocktail Therapy on Metabolic, Endocrine Alterations and Perceived Stress in Patients With Poly Cystic Ovary Syndrome
|
Phase 2 | |
| Completed |
NCT04562883 -
Single vs. Group CAPA-IVM Culture of Cumulus-oocyte Complexes
|
N/A | |
| Recruiting |
NCT03264638 -
A Clinical and Biological Research of Combined Chinese and Western Medicine in the Treatment of PCOS
|
Phase 2 | |
| Completed |
NCT00594217 -
Determining How Quickly Progesterone Slows LH Pulse Frequency
|
Phase 1 | |
| Recruiting |
NCT02024984 -
Luteal Phase Versus Follicular Phase Administration of Clomiphene Citrate in PCOS, A Randomized Controlled Trial
|
Phase 1 | |
| Completed |
NCT01709942 -
Use of Degarelix in Controlled Ovarian Hyperstimulation (COH) Protocol for Women With PoliCystic Ovarian Syndrome (PCOS)
|
Phase 3 |