PCOS Clinical Trial
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of
reproductive age and is characterized by menstrual abnormalities, clinical or biochemical
hyperandrogenism, multiple abnormal cysts and enlarge ovaries. Women affected by PCOS often
suffer of insulin resistance and of a compensatory hyperinsulinemia which put them at risk
of developing several metabolic disorders. Inositol is a six-carbon polyol which has been
characterized as an insulin sensitizer: it exists as nine different isomers and among them
myo-inositol and D-chiroinositol are the most represented and studied in physiology and
physiopathology. In particular, myo-inositol (MI) and D-chiro inositol (DCI) glycans
administration has been reported to exert beneficial effects at metabolic, hormonal and
ovarian levels.
The aim of this randomized study is to evaluate the metabolic and ovaric effects of a
six-month supplementation of myo-inositol and D-chiro-inositol on young women with PCOS and
hyperinsulemia.
n/a
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