PCOS Clinical Trial
Insulin resistance has important implications in the pathogenesis of the polycystic ovary
syndrome (PCOS) and insulin-sensitizing drugs are considered a useful therapeutic approach.
Reduction of insulin levels with administration of insulin sensitizing agents has been found
to be beneficial in lowering both hyperinsulinemia, hyperandrogenemia, and restoring
ovulation. Metformin alone or in combination with oral contraceptives (OCs) has been widely
used in the long term treatment of women with PCOS in whom it modifies the ovarian
morphology, improves intraovarian androgen levels, and enhances systemic and local insulin
resistance. Despite to these beneficial effects, several side effects have been reported due
to the long term administration of this drug.
In the recent years, inositol has found more and more space in the reproductive clinical
practice. Indeed, inositol have been classified as "insulin sensitizing agent" and it is
mainly used as a chronic treatment for PCOS. Inositol exists in 9 different isomers and in
particular several studies on Myo-inositol and D-chiro-inositol were reported.
In this study myo-inositol versus D-chiro-inositol treatments were compared to placebo in
women with PCOS and with or without insulin resistance.
n/a
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
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|
||
| Not yet recruiting |
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||
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