Bendamustine-based Combination Therapy for PCNSL

PCNSL Clinical Trial

Official title:

Plasma and Cerebrospinal Fluid (CSF) Pharmacokinetics of Bendamustine as a Component of Salvage Therapy for Primary Central Nervous System Lymphoma (PCNSL)

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03392714
• Other study ID #: CNUHH-2016-145
• Status: Active, not recruiting
• Phase: Phase 2
• First received: December 6, 2017
• Last updated: January 2, 2018
• Start date: January 20, 2016
• Est. completion date: January 20, 2019

Study information

• Verified date: January 2018
• Source: Chonnam National University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This pilot study will i) evaluate the efficacy and the safety of bendamustine-based combination chemotherapy and ii) investigate the pharmacokinetics (PK)of bendamustine in plasma and CSF when given as salvage treatment for patients with relapsed or refractory primary central nervous system lymphoma (PCNSL).

Description:

A relatively high proportion of patients diagnosed with primary CNS lymphoma will experience recurrent disease, yet therapy options are limited in salvage therapy. Based on the demonstrated activity and proposed additive mechanisms of the chemotherapeutic agents included in the bendamustine-based combination regimen, the efficacy and safety of R-B(O)AD will be evaluated for treatment of relapsed/refractory (R/R) primary CNS lymphoma. Evidence from previous preclinical tissue distribution studies and single agent intravenous drug therapy trials in CNS malignancies suggests that bendamustine penetrates brain and tumor tissue, however there are no clinical data available on the PK of bendamustine in the CSF. This study will evaluate the PK of plasma and CSF drug levels through a population based nonlinear mixed-effects model approach in a R/R PCNSL cohort with the goals to define the currently unknown PK profile of bendamustine in the CSF and to further characterize the relationship between plasma and CSF drug levels, and the influence of exposure on response to therapy.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 15
• Est. completion date: January 20, 2019
• Est. primary completion date: January 20, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years and older

Eligibility

Inclusion Criteria:

1. PCNSL of diffuse large B-cell lymphoma (DLBCL) with a CNS lesion by tissue biopsy

2. Age = 19 years old

3. Relapsed or refractory PCNSL after frontline combined chemotherapy or radiation

4. ECOG performance status 0-2

5. Absolute neutrophil count = 1000/uL

6. Platelets = 100,000/uL

7. Total bilirubin = 1.5 x ULN (upper limit of normal)

8. Aspartate aminotransferase (AST) = 3 x ULN

9. Creatinine = 2.0 x ULN

Exclusion Criteria:

1. PCNSL of other than DLBCL or T-cell lymphoma with a CNS lesion by tissue biopsy

2. Any of the following: pregnant women, nursing women, men or women of childbearing potential who are unwilling to employ adequate contraception

3. Uncontrolled infection

4. Therapy with myelosuppressive chemotherapy or biologic therapy < 21 days prior to registration

5. Persistent toxicities = grade 3 from prior chemotherapy or biologic therapy regardless of interval since last treatment

6. History of thromboembolic episodes = 3 months prior to registration

7. Active hepatitis B or C with uncontrolled disease

8. Active other malignancy requiring treatment that would interfere with the assessments of response of the lymphoma to protocol treatment

9. Any severe and/or uncontrolled medical conditions or other conditions that could adversely impact their ability to participate in the study

10. Major surgery = 4 weeks prior to registration or have not recovered from side effects of such therapy

Related Conditions & MeSH terms

• PCNSL

Intervention

Drug:
• R-B(O)AD
rituximab 375 mg/m2 on day 1; vincristine 1.4 mg/m2 on day 1, omitted in patients =70 years of age due to risk of neurotoxicity; bendamustine 75 mg/m2 over 1 h on days 2 and 3; cytarabine 1000 mg/m2 over 3 h on days 2-4; dexamethasone 20 mg on days 1-4, administered intravenously

Locations

Country	Name	City	State
Korea, Republic of	Chonnam National University Hwasun Hospital	Hwasun-gun	Jeollanam-do

Sponsors (1)

Lead Sponsor	Collaborator
Chonnam National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Overall response rate (ORR)	rate of complete or partial response (CR/PR)	2 year
Secondary	Toxicity based on NCI Common Terminology Criteria version 4.0	adverse event incidence of combination regimen	2 year
Secondary	Progression-free survival (PFS)	calculated from the time of study entry until progression, relapse, or death	2 years
Secondary	Overall survival (OS)	calculated from the time of study entry until death	2 years
Secondary	Maximum concentration [Cmax] of bendamustine in plasma and CSF	peak concentration of bendamustine after 1 hour IV infusion	6 months
Secondary	Area under the curve [AUC] of bendamustine in plasma and CSF	overall exposure of bendamustine after IV infusion	6 months