Patients With Chronic Migraine Clinical Trial
Official title:
Acupuncture in Chronic Migraine: A Randomized Controlled Trial
The aim of this study was to investigate the efficacy and tolerance of acupuncture treatment compared with pharmacologic treatment in patients with chronic migraines.Besides, the investigators tested whether the clinical effects of acupuncture in chronic migraine prophylaxis are mediated by changes of the plasma CGRP (Calcitonin gene-related peptide).
Subjects who completed the prospective baseline periods and meet met the prespecified entry
criteria will be randomized into 2 groups: acupuncture treatment, and topiramate treatment
group.
Subjects will be allowed to continue taking acute migraine medications for the treatment of
breakthrough attacks during the trial, but any migraine preventive medications will be
prohibited.
Written informed consent was obtained from all participants before entering the study.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment