Review of Isolated Hypoganglionosis and Presentation of a New Case Complicated With Sigmoid Volvulus

Pathology Clinical Trial

Official title:

Systematic Review of Isolated Hypoganglionosis and Presentation of a New Case Complicated With Sigmoid Volvulus

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04363125
• Other study ID #: 23042020
• Status: Completed
• Start date: January 1, 2019
• Est. completion date: April 20, 2020

Study information

• Verified date: April 2020
• Source: Dr. Ersin Arslan Education and Training Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Isolated hypoganglionosis is rare and constitutes 3-5% of all congenital neurological bowel diseases. Since hypoganglionosis is associated with symptoms such as chronic constipation or pseudo-obstruction, it can be confused with Hirschprung's disease and it is important to make a differential diagnosis before treatment. Our aim in this study; In addition to sharing the rarely isolated hypoganglionosis and sigmoid volvulus in a 45-year-old male patient with mental retardation, the investigators present a systematic comprehensive review of hypoganglionosis.

Description:

Isolated hypoganglionosis is rare and constitutes 3-5% of all congenital neurological bowel diseases. Since hypoganglionosis is associated with symptoms such as chronic constipation or pseudo-obstruction, it can be confused with Hirschprung's disease and it is important to make a differential diagnosis before treatment. Our aim in this study; In addition to sharing the rarely isolated hypoganglionosis and sigmoid volvulus in a 45-year-old male patient with mental retardation, the investigators present a systematic comprehensive review of hypoganglionosis. Pubmed and Scopus databases were scanned. No restrictions were used in the written language. Only isolated cases of hypoganglionosis were added to the study. In the cases; author, year of publication, country of publication, age, gender, surgical or non-surgical treatments, treatment results, and mortalities were examined.

When sigmoid volvulus is seen in children and adolescents, congenital neurological bowel diseases should be considered in the differential diagnosis. Hirschprung's disease must be ruled out by rectal biopsy. The histopathological investigation should be carried out for the diagnosis and determination of surgical margins in isolated hypoganglionosis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 310
• Est. completion date: April 20, 2020
• Est. primary completion date: April 1, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• isolated hypoganglionosis

• our case of isolated hypoganglionosis

Exclusion Criteria:

• hypoganglionosis with Hirschsprung's disease

Related Conditions & MeSH terms

• Hypoganglionosis
• Intestinal Volvulus
• Pathology
• Sigmoid Volvulus

Intervention

Diagnostic Test:
• Pathology result
Pathology result of rectal biopsy

Locations

Country	Name	City	State
Turkey	Dr. Ersin Arslan Training and Resource Hospital	Gaziantep

Sponsors (2)

Lead Sponsor	Collaborator
Dr. Ersin Arslan Education and Training Hospital	Inonu University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Mortality	Mortality of sigmoid volvulus due to isolated hypoganglionosis	three months