Genomewide Screening of Pathological Myopia

Pathological Myopia Clinical Trial

Official title:

Genomewide Screening of Pathological Myopia

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00155753
• Other study ID #: 9100205245
• Status: Recruiting
• Phase: N/A
• First received: September 9, 2005
• Last updated: June 8, 2010
• Start date: August 2002
• Est. completion date: August 2010

Study information

• Verified date: April 2010
• Source: National Taiwan University Hospital
• Contact: Yung-Feng Shih, MD
• Phone: 886-2-23123456
• Email: yfshih[@]ha.mc.ntu.edu.tw
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to evaluate the possible candidate gene of pathological myopia

Description:

High myopia (pathological myopia) is caused by excessive axial elongation that primarily involves the ora-equatorial area and the posterior pole. Peripheral fundus changes and posterior staphyloma formation are ophthalmoscopic evidences of this process. Pathological myopia often accompanied by glaucoma, cataracts, macular degeneration, and retinal detachment, leading to blindness when the damage to the retina is extremely severe. Population and family studies in Chinese have provided evidence for a genetic component to pathologic myopia. Children of myopic parents are more likely to have myopia than are children of nonmyopic parents. The ocular components (axial length, anterior chamber depth, and corneal curvature) and refractive errors of MZ twins are more closely aligned than are those of DZ twins.

Therefore, it is possible to search a potential candidate gene for myopia through the genomic study of pathological myopia.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 600
• Est. completion date: August 2010
• Est. primary completion date: August 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• They are unrelated Chinese subjects with high myopia ?-6.00D. The diagnosis of myopia is determined by the refractive error. Anisometropic individuals, with a refractive error of ?-6.00 D for one eye and ?-6.00 D for the other eye, with at least a 2-D difference between the two eyes, are considered unaffected.

Exclusion Criteria:

• Individuals are excluded if there is known ocular disease or insult that could predispose to myopia, such as retinopathy of prematurity or early-age media opacification, or if they had a known genetic disease associated with myopia, such as Stickler or Marfan syndrome.

Study Design

Observational Model: Case Control

Related Conditions & MeSH terms

• Myopia
• Myopia, Degenerative
• Pathological Myopia

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan,