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Clinical Trial Summary

Patent foramen ovale arises from the incomplete postnatal fusion of the septum primum and secundum and can cause paradoxical embolism in adults. In case of cerebral ischemic stroke, the correlation with the patent foramen ovale is based on probabilistic approach. For this reason, continuous research is indispensable, especially according to new approaches, to offer tools capable of guiding in case of adverse event with greater certainty and even better to prevent it. Thus, this study aims to: 1) evaluate the microstructural brain damage through advanced MRI analysis in patients with patent foramen ovale; 2) evaluate how much the degree of the shunt can affect brain damage. In order to do this, this study aims to evaluate advanced brain imaging in a cohort of patients with patent foramen ovale to identify the development of early vascular damage.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT04549272
Study type Observational
Source Neuromed IRCCS
Contact Giuseppe Lembo, MD, PhD
Phone +390865915225
Status Not yet recruiting
Start date October 2022
Completion date October 2023

See also
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