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Assessment of Early Vascular Damage With Advanced Neuroimaging in Patient With Patent Foramen Ovale

Patent Foramen Ovale Clinical Trial

Official title:
Assessment of Early Vascular Damage With Advanced Neuroimaging in Patient With Patent Foramen Ovale

Clinical Trial Summary

Patent foramen ovale arises from the incomplete postnatal fusion of the septum primum and secundum and can cause paradoxical embolism in adults. In case of cerebral ischemic stroke, the correlation with the patent foramen ovale is based on probabilistic approach. For this reason, continuous research is indispensable, especially according to new approaches, to offer tools capable of guiding in case of adverse event with greater certainty and even better to prevent it. Thus, this study aims to: 1) evaluate the microstructural brain damage through advanced MRI analysis in patients with patent foramen ovale; 2) evaluate how much the degree of the shunt can affect brain damage. In order to do this, this study aims to evaluate advanced brain imaging in a cohort of patients with patent foramen ovale to identify the development of early vascular damage.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04549272
Study type Observational
Source Neuromed IRCCS
Contact Giuseppe Lembo, MD, PhD
Phone +390865915225
Email lembo@neuromed.it
Status Not yet recruiting
Phase
Start date October 2022
Completion date October 2023
View Details
See also
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Active, not recruiting NCT04738071 - International Multicenter Patent foRamen OVale & strokE (IMPROVE) Registry
Not yet recruiting NCT06413147 - Long-term Procedural and Device Related Complications of PFO Closure
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Withdrawn NCT02378623 - Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli Phase 2