Neural Mechanisms of Muscle Control in Individuals With Knee Pain

Status Terminated

Clinical Trial Summary

This is a randomized controlled trial of knee muscle versus hip muscle strengthening for Patellofemoral Pain Syndrome.

Clinical Trial Description

Rationale: Two prior randomized controlled trials (RCT) have highlighted the importance of hip muscle activation and strengthening as a treatment strategy for patellofemoral pain (Khayambashi, 2014; Khayambashi, 2012). Here, we propose a pilot study to acquire preliminary data to power a larger study to reveal the neural mechanism underlying the effectiveness of this intervention to promote its evidence-based incorporation into clinical practice.

Intervention: 4 weeks of quadriceps muscle versus 4 weeks of hip strengthening exercises.

Purpose: To determine changes in brain functional connectivity related to pain reduction induced by the strengthening exercises.

Study population: Males and females with a history of unilateral knee pain.

Methodology: Functional magnetic resonance imaging (fMRI) will be used to quantify functional connectivity of brain regions related to hip muscle activation. Functional connectivity will be quantified before (pre) and after (post) 4 weeks of quadricep or hip muscle strengthening exercises.

Arms: As above, there are 2 arms. 4 weeks of quadriceps strengthening exercises (Arm 1) versus 4 weeks of hip strengthening exercises (Arm 2).

Outcomes: At the pre and post-intervention sessions in each participant, we will quantify the brain functional connectivity between hip muscle motor cortex and the 1) thalamus, 2) basal ganglia, and 3) insula, and 4) the periaqueductal gray. We will also quantify self-report of pain and biomechanical function of the knee and hip.

Follow-up: A six month follow-up is planned for this pilot study.

Analysis Plan and Statistics: Functional connectivity of hip muscle motor cortex will be extracted using standard statistical software for brain mapping. A repeated measures ANOVA will be used to assess change in functional connectivity in the hip and knee group. Pain decreases in the both groups will be quantified and reported. ;

Study Design

Related Conditions & MeSH terms

Patellofemoral Pain Syndrome

Clinical Trial Details

NCT number	NCT02854774
Study type	Interventional
Source	University of Southern California
Contact
Status	Terminated
Phase	Early Phase 1
Start date	August 30, 2016
Completion date	November 11, 2016

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04538508` - Radiofrecuency and Supervised Exercise Versus Supervised Exercise in the Treatment of Patellofemoral Pain Syndrome.	N/A
Completed	`NCT03685812` - Validity and Reliability of Autocad Software Assessment of JPS in PFPS
Completed	`NCT02873143` - 5 Year Follow-up of Adolescents With Knee Pain	N/A
Active, not recruiting	`NCT02114294` - Hip Strengthening Versus Quadriceps Based Training for Patellofemoral Pain Syndrome	N/A
Completed	`NCT02243332` - Dynamic Quadriceps Muscle Stimulation for Treatment of Patellofemoral Pain	N/A
Completed	`NCT01696162` - Conventional Home Exercise Programs Versus Electronic Home Exercise Versus Artificial Intelligence "Virtual Therapy" for Anterior Knee Pain	N/A
Completed	`NCT01434966` - Changes in Quadriceps Function Following Local or Distant Interventions in Individuals With Patellofemoral Pain	N/A
Not yet recruiting	`NCT05327569` - The Efficacy of Myofascial Chain Release Techniques in Patients With Patellofemoral Pain Syndrome.	N/A
Completed	`NCT06060730` - Measurement Properties of the Turkish Version of the Patellofemoral Pain and Osteoarthritis Subscale of the KOOS
Completed	`NCT03281421` - Immediate Effects of Ankle Mobilization on Dorsiflexion Range of Motion in Women With Patellofemoral Pain.	N/A
Recruiting	`NCT06130696` - Clamshell Exercise in Patellofemoral Syndrome.	N/A
Completed	`NCT03201133` - Clinical Subgroups in Patellofemoral Pain Syndrome
Completed	`NCT05959148` - Adjuvant Effects of Monochromatic Infrared Energy in Rehabilitation of Adolescents With Patellofemoral Pain Syndrome	N/A
Completed	`NCT02646579` - Effects of Dry Needling Using Spinal and Peripheral Sites Versus Peripheral Sites Only	N/A
Completed	`NCT00978003` - Vasti Control of Patellofemoral Kinematics in Asymptomatic Volunteer
Not yet recruiting	`NCT05383781` - Effect of Short Foot Exercise in Treatment of Patients With Patellofemoral Pain Syndrome	N/A
Not yet recruiting	`NCT05083897` - Effect of Hip Adductors Isometric Contraction on Knee Extensors Isokinetic Torque in Patellofemoral Pain Syndrome
Withdrawn	`NCT03157271` - The Addition of Dry Needling in the Treatment of Patients With Patellofemoral Pain Syndrome	N/A
Enrolling by invitation	`NCT02548988` - Selective Neuromuscular Electrical Stimulation on VMO	N/A
Completed	`NCT01975311` - Effect of Lower Back Treatment in People With Patellofemoral Pain Syndrome.	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.