Seizures Clinical Trial
Official title:
Drug Refractory Partial Epilepsy, A Therapeutic Trial With Transcranial Magnetic Stimulation
Transcranial Magnetic Stimulation (TMS) is a non-invasive technique that can be used to
stimulate brain activity and gather information about brain function. It is very useful when
studying the areas of the brain related to motor activity (motor cortex, corticospinal
tract, and corpus callosum).
Epilepsy is a condition associated with seizures as a result of an over excitable cerebral
cortex. Despite the introduction of several new antiepileptic medications, less than half of
the patients diagnosed with partial epilepsy are well controlled. However, studies have
shown that non-invasive stimulation of the brain can decrease the excitability of the
cerebral cortex.
Researchers are interested in the potential therapeutic effects of TMS on patients with
epilepsy that have responded poorly to standard medication. This study will use TMS to
decrease the excitability of the areas of the brain responsible for seizures.
The purpose of this protocol is to study the effects of transcranial magnetic stimulation (TMS) at 1 Hz on the excitability of the seizure focus in patients with poorly controlled epilepsy refractory to pharmacological treatments. 1 Hz TMS is a rate proven to induce long term depression in animal models and reported to decrease the excitability of both human and animal cerebral cortex. ;
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