Parodontosis Clinical Trial
Official title:
Immunoregulation of Periodontal Diseases
Periodontal diseases are a group of diseases that affect 15% of the population and in the absence of treatment causes tooth loss. Periodontal lesions are characterized mainly by strong inflammation and hyper-vascularization. Search in blood cells and inflammatory markers attempts to explain the etiological-pathogenetic mechanisms. Innate immunity can be assessed by qualitative and quantitative analysis of blood phagocytes, natural killer cells, complement, proteins of inflammation and cytokines. Current data from the literature on this subject give contradictory results and the comparison of studies are difficult because the diversity of the populations studied, evaluated cells and the methods used. The aim of the study was to evaluate the innate immunity of patients with periodontal disease and compare it with a group of patients without periodontal disease.
Periodontal diseases are a group of diseases that affect 15% of the population and in the
absence of treatment causes tooth loss. Periodontal lesions are characterized mainly by
strong inflammation and hyper-vascularization. Search in blood cells and inflammatory
markers attempts to explain the etiological-pathogenetic mechanisms. Innate immunity can be
assessed by qualitative and quantitative analysis of blood phagocytes, natural killer cells,
complement, proteins of inflammation and cytokines. Current data from the literature on this
subject give contradictory results and the comparison of studies are difficult because the
diversity of the populations studied, evaluated cells and the methods used. The aim of the
study was to evaluate the innate immunity of patients with periodontal disease and compare
it with a group of patients without periodontal disease. The previous conclusions of study
focused on the difference in the general immunological parameters in healthy patients and
patients suffering from periodontal disease, current advances in immunology have helped to
develop new markers on functional status of blood phagocytes all through their
anti-microbial action. The adhesion, migration, phagocytosis and bactericidal capacity are
assessed and quantified using recognized tests and practiced regularly in analytical
laboratory. The identification of altered immunological parameters in patients with
periodontal disease would better understand the natural history of these diseases and may
lead to new diagnostic criteria, prognostic and therapeutic.
In practice, the project brings together immunological skills (functional analysis of cells
and membrane markers) and dental (patient selection and diagnosis of periodontal disease)
for further testing applicable to many patients likely to develop periodontal disease.
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Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic