Parkinsonian Syndrome Clinical Trial
Official title:
Dynamic SPECT Imaging With [123I] B-CIT in Individuals With Parkinsonian Syndrome (PS) and in Individuals at Risk for Parkinsonian Syndrome
This study involves study participants who have been clinically diagnosed with parkinsonian syndrome or who are at-risk for parkinsonian syndrome, have a family history of parkinsonian syndrome or exposure to environmental toxins potentially associated with parkinsonian syndrome. Participants will have brain imaging to assess dopamine transporter density. The imaging data coupled with family history and environmental exposure data may provide important information about potential risk factors for parkinsonian syndrome.
The brain imaging is conducted at the Institute for Neurodegenerative Disorders in New
Haven, Connecticut. The imaging procedure occurs over a two day period.
On the first day participants are injected with [123I]ß CIT, an investigational radioactive
material that localizes in the brain. Study participants will also have a thorough
neurologic examination and standard neuropsychological testing, including testing of memory,
concentration, abstraction and visual spatial functions.
Twenty-four hours later study participants return to the Institute for Neurodegenerative
Disorders where an investigational scanning procedure will be used to obtain SPECT (single
photon emission computed tomography) images of the brain.
Participants may be contacted to repeat these procedures every 12 to 18 months.
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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