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Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium

Breast Cancer Clinical Trial

Official title:
A Single-arm, Multicenter, Proof-of-concept Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium Despite Recent Treatment With IV Bisphosphonates

Clinical Trial Summary

The purpose of this study is to determine the potential of denosumab to treat Hypercalcemia of Malignancy in patients with elevated serum calcium who do not respond to recent treatment with intravenous bisphosphonates by lowering corrected serum calcium </= 11.5 mg/dL (2.9 millimoles /L) by day 10.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Breast Cancer
  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Renal Cell
  • Colon Cancer
  • Endocrine Cancer
  • Endocrine Gland Neoplasms
  • Head and Neck Cancer
  • Head and Neck Neoplasms
  • Hodgkin Disease
  • Hodgkin's Lymphoma
  • Hypercalcemia
  • Hypercalcemia of Malignancy
  • Kidney Cancer
  • Kidney Neoplasms
  • Lung Cancer
  • Lung Neoplasms
  • Lymphoma
  • Lymphoma, Non-Hodgkin
  • Metastatic Cancer
  • Multiple Myeloma
  • Neoplasm Metastasis
  • Neoplasms
  • Non-Hodgkin's Lymphoma
  • Non-Small Cell Lung Cancer
  • Paraneoplastic Syndromes
  • Parathyroid Neoplasms
  • Renal Cancer
  • Thyroid Cancer
  • Thyroid Neoplasms
Clinical Trial Details
NCT number NCT00896454
Study type Interventional
Source Amgen
Contact
Status Completed
Phase Phase 2
Start date November 16, 2009
Completion date August 21, 2013
View Details
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