Parasite IBS IBD Clinical Trial
Official title:
Role of Parasitic Infection in Inflammatory Bowel Disease and Irritable Bowel Syndrome
Role of parasitic infection in Inflammatory bowel disease and Irritable bowel The burden of the parasitic disease is in-direct relation with the health and nutritional status of the host, inducing not only parasite-specific immunity but also can modify the host's immune responses . Many parasites can imitate inflammatory bowel disorders and some studies showed that infection with parasites can improve disorders like IBD or moderate the symptoms of inflammatory bowel disorders . Even though, many studies have shown that gastrointestinal infection is an important risk factor for the development of IBS
| Status | Recruiting |
| Enrollment | 300 |
| Est. completion date | June 2024 |
| Est. primary completion date | June 2024 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 17 Years to 69 Years |
| Eligibility | Inclusion Criteria: - Diagnosis of IBD will be confirmed using 1. standard clinical, 2. endoscopic, 3. radiographic and4 pathological criteria according to the Montreal classification of the extent and severity of IBD - Diagnosis of IBS will depend on Rome IV criteria 1. Recurrent abdominal pain on average at least 1 day/week in the last 3 months, 2. associated with two or more of the following criteria: 3. Related to defecation; 4. Associated with a change in the frequency of stool and/ or Associated with a change in the form (appearance) of stool. Exclusion Criteria: - any patient who received antipiotic or antiparasitic drug within the past 4 weeks |
| Country | Name | City | State |
|---|---|---|---|
| Egypt | Marina Gamil Shwqi | Assiut |
| Lead Sponsor | Collaborator |
|---|---|
| Assiut University |
Egypt,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Detect the prevalence of parasite/s associated with Inflammatory bowel diseases (IBD) and Irritable bowel syndrome (IBS) in comparison with control subjects. | Detect the prevalence of parasite/s associated with Inflammatory bowel diseases (IBD) and Irritable bowel syndrome (IBS) in comparison with control subjects.by making stool analysis and clinical examination | baseline | |
| Secondary | measure the effect of the antiparasitic drugs on the course and prognosis of the diseases | giving the patient antiparasitic drug and measure the effect of anti parasitic drug on course and prognosis of disease | baseline |