Paraquat Poisoning Clinical Trial
Official title:
Low Dose Euthyrox in Treatments of Paraquat Intoxication: a Randomized, Controlled, Multicenter Trial in China.
Paraquat is a common human toxicant and accounts for 20 deaths per million persons in the
world. Paraquat usually cause multiple organ dysfunction syndrome, including liver, kidney,
lung and heart dysfunction. Besides, pituitary insufficiency also occurs on those patients
with paraquat poisoning, which leads to multiple endocrine gland dysfunction, involving
adrenal gland, thyroid and sex gland.
As a result, the investigators decide to initiate the clinical trial to find whether thyroid
replacement therapy can furtherly reduce the mortality, and improve patients long-term
prognosis.
Paraquat is a common human toxicant and accounts for 20 deaths per million persons in the
world. Its accidental or deliberate ingestion is associated with a high mortality rate
ranging from 40% to 70%. Paraquat usually cause multiple organ dysfunction syndrome,
including liver, kidney, lung and heart dysfunction. Besides, pituitary insufficiency also
occurs on those patients with paraquat poisoning, which leads to multiple endocrine gland
dysfunction, involving adrenal gland, thyroid and sex gland. Nowadays, steroids, as a hormone
replacement therapy, is one of most important drugs for paraquat poisoning, and it has
decreased patients' mortality greatly since using it. However, the clinicians have not paid
enough attention to thyroid replacement therapy, as thyroid dysfunction is also the key
pathophysiological course when paraquat poisoning occurs.
As a result, the investigators decide to initiate the clinical trial to find whether thyroid
replacement therapy can furtherly reduce the mortality, and improve patients long-term
prognosis.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT02444858 -
Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Paraquat Poisoning Induced Lung Injury
|
Phase 1/Phase 2 |