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Paraesophageal Hernia clinical trials

View clinical trials related to Paraesophageal Hernia.

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NCT ID: NCT06193551 Recruiting - Clinical trials for Paraesophageal Hernia

Ovitex in Paraesophageal and Large Hiatal Hernia Repair

OviPHeR
Start date: February 19, 2024
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate the success of hiatal hernia repairs in patients with large (>5cm) or paraesophageal hernias when Ovitex LPR mesh used during the repair.

NCT ID: NCT06107634 Recruiting - Clinical trials for Paraesophageal Hernia

Gastropexy in the Repair of Patients With Paraesophageal Hernias

PEH3
Start date: June 1, 2023
Phase: N/A
Study type: Interventional

Patients scheduled for surgery for primary paraesophageal herniation are randomized to either conventional surgical hernia repair or with the addition of gastropexy.

NCT ID: NCT06096402 Not yet recruiting - Clinical trials for Paraesophageal Hernia

Gastropexy as a Treatment Option for Paraesophageal Hernia

Start date: June 1, 2024
Phase:
Study type: Observational

The present proposal aims to asses which is the optimal treatment strategy in a clinical study in patients with paraoesophageal hernia (PEH), a condition often found in elderly, fragile patients The investigator want to study the optimal approach to a paraoesophageal hernia (PEH) repair. The incidence of PEH increases with age and the older patient typically has additional co-morbidities, reduced physiological fitness, and frailty which makes surgery challenging regarding increased morbidity and mortality. Thus, the decision to offer surgery can be challenging in this cohort of patients. The need of an anti-reflux procedure as part of the repair is one of the main subjects for discussion worldwide. To date no consensus exists and many surgical centres do a routine anti-reflux procedure as part of their standard operation for PEH. But is this procedure redundant? Can the patients be managed with a less complicated procedure; an anterior gastropexy with comparable outcome?

NCT ID: NCT05974722 Recruiting - GERD Clinical Trials

Mesh Vs Pledgets for Repair of Paraesophageal Hernia

Start date: September 11, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at the Cleveland Clinic. The main questions it aims to answer are: - Determine whether there is a difference in 2-year rates of radiographic recurrence with Ovitex versus pledgeted sutures in paraesophageal hernia repair. - Assess patient quality of life (QOL) after paraesophageal hernia repair with pledgets and mesh. A two-tailed research hypothesis will be used to determine whether there are differences between the two arms

NCT ID: NCT05807763 Enrolling by invitation - Clinical trials for Paraesophageal Hernia

Fundoplication in Laparoscopic PEH Repair Based on FLIP

PEHFLIP
Start date: February 22, 2023
Phase: N/A
Study type: Interventional

Prospective randomized controlled trial to identify a sub-set of patients that do not benefit from the routine addition, and added morbidity, of a fundoplication during laparoscopic paraesophageal hernia repair.

NCT ID: NCT05201508 Recruiting - Recurrence Clinical Trials

Sutures Versus Polyglactin Mesh in Hiatal Hernia Repair

Start date: January 21, 2022
Phase: N/A
Study type: Interventional

Paraesophageal hernia causes pain, heartburn, regurgitation, anemia and in extreme, life-threatening strangulation. For symptomatic patients, laparoscopic surgery is offered which includes hiatal defect closure and antireflux surgery. However, recurrence rates are high between 12 and 42%. In order to reduce recurrences, mesh has been used with various materials and techniques with conflicting results. Non-absorbable mesh has been linked with adverse events including erosion of esophageal wall. Traditionally used biological mesh materials are expensive and therefore problematic in routine use. Use of polyglactin (Vicryl®) mesh, which degrades in 6-8 week, has been reported in paraesophageal hernia surgery. Previously, no randomized controlled trial comparing sutures only and polyglactin mesh has been performed. In this trial, the aim was to randomize total of 110 patients to receive sutures only or mesh repair. Primary outcome was recurrence of paraesophageal hernia at 6 months after the repair based on computed tomography scan. Secondary outcomes included symptomatic recurrences, reoperation rate, quality of life, reoperations up to 20-years after surgery and use of proton pump inhibitors up to 20-years after surgery.

NCT ID: NCT04436159 Completed - Clinical trials for Gastro Esophageal Reflux

Partial Versus Total Fundoplication in the Surgical Repair of Para-esophageal Hernia.

Start date: May 1, 2009
Phase: N/A
Study type: Interventional

Short-term follow up after surgery of para-esophageal hernia comparing two different types of fundoplication

NCT ID: NCT04179578 Active, not recruiting - Clinical trials for Paraesophageal Hernia

The Value of Lateral Release in Reconstruction of the Diaphragmatic Hiatus Hernia

PEH2
Start date: July 16, 2019
Phase: N/A
Study type: Interventional

Patients scheduled for surgery for primary paraesophageal herniation are randomized to either conventional suturing of the crura or with the addition of lateral release.

NCT ID: NCT04007952 Completed - Clinical trials for Paraesophageal Hernia

Anterior Gastropexy vs. No Anterior Gastropexy for Paraesophageal Hernia Repair

Start date: June 26, 2019
Phase: N/A
Study type: Interventional

This study evaluates the effect of anterior gastropexy (one or more sutures fixing the stomach to the inner abdominal wall) on improving durability of paraesophageal hernia repair. Half of participants will receive anterior gastropexy, while the other half will not. The hypothesis is that anterior gastropexy will help to prevent paraesophageal hernias from recurring.

NCT ID: NCT03058731 Completed - Clinical trials for Paraesophageal Hernia

ACELL Mesh for Paraesophageal Hernia Repair

Start date: February 2, 2016
Phase:
Study type: Observational

This is a prospective, case-matched, systematic follow up of up to 70 pre-existing patients whom underwent paraesophageal hernia repair between June 1, 2012 and September 30, 2016. Patients whom are willing to participate in the study will be asked to return for a one time follow up visit to reassess for hiatal hernia recurrence both symptomatically and radiologically to compare the efficacy of the use of MatriStem Surgical Matrix (ACell) mesh to other biologic meshes.