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Clinical Trial Summary

Oxidative stress (OS) could be involved in the progression of papillary thyroid cancer (PTC). Indeed, thyroid differentiation genes are silenced by a mechanism controlled by NOX4-derived OS. On the other hand, TERT contributes to mitochondrial OS protection, which could increase the resistance of cancer cells to therapeutic agents. The investigators aim to address the role of OS and mitochondrial TERT in the progression and therapeutic resistance of PTC. OS and TERT subcellular localization will be investigated in 150 PTCs and correlated to the genetic and expression profile of the tumors and to the clinical and prognostic features of the patients. Mechanisms implicated in TERT mitochondrial migration and the contribution of mitochondrial TERT to tumor progression will be investigated in cancer cell lines and primary cell cultures. This study will allow to identify OS as a marker of therapeutic resistance in PTC and will open new opportunities for the development of novel treatments targeting ROS generation/TERT nuclear export.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05752669
Study type Observational
Source Istituto Auxologico Italiano
Contact Marina Muzza, PhD
Phone +390261911
Email m.muzza@auxologico.it
Status Recruiting
Phase
Start date September 15, 2021
Completion date May 31, 2024

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