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Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) — STARTRK-2  

Breast Cancer Clinical Trial

Official title:
An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements

Clinical Trial Summary

This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Adult Solid Tumor
  • Brain Neoplasms
  • Breast Cancer
  • Carcinoma, Non-Small-Cell Lung
  • Cholangiocarcinoma
  • Colorectal Cancer
  • Colorectal Neoplasms
  • Head and Neck Neoplasms
  • Lymphoma, Large-Cell, Anaplastic
  • Melanoma
  • Neoplasms
  • Neuroendocrine Tumors
  • Non-Small Cell Lung Cancer
  • Ovarian Cancer
  • Ovarian Neoplasms
  • Pancreatic Cancer
  • Pancreatic Neoplasms
  • Papillary Thyroid Cancer
  • Primary Brain Tumors
  • Renal Cell Carcinoma
  • Salivary Gland Cancers
  • Salivary Gland Neoplasms
  • Sarcoma
  • Sarcomas
  • Thyroid Cancer, Papillary
  • Thyroid Neoplasms
Clinical Trial Details
NCT number NCT02568267
Study type Interventional
Source Hoffmann-La Roche
Contact
Status Active, not recruiting
Phase Phase 2
Start date November 19, 2015
Completion date April 1, 2025
View Details
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