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NCT01680107 Clinical Trial

D-cycloserine Augmented CBT for Panic Disorder

Panic Disorder Clinical Trial

Official title:
The Effect of a Single-dose of D-cycloserine on the Basic Effects of Cognitive-behaviour Therapy for Panic Disorder - a Randomized Placebo-controlled Trial

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT01680107
Other study ID # MRC-01
Secondary ID 2012-003191-39
Status Terminated
Phase Phase 3
First received
Last updated
Start date October 2012
Est. completion date April 30, 2018

Study information
Verified date May 2018
Source University of Oxford
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to determine whether d-cycloserine augments the clinical effects of exposure-based cognitive-behaviour therapy for panic disorder.

Recruitment information / eligibility
Status Terminated
Enrollment 33
Est. completion date April 30, 2018
Est. primary completion date October 31, 2017
Accepts healthy volunteers No
Gender All
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- clinical diagnosis of panic disorder

- at least moderate agoraphobic avoidance

Exclusion Criteria:

- psychoactive medication last 6 weeks

- exposure-based cognitive-behaviour treatment for panic disorder and agoraphobia during last 3 months

- female participant who is pregnant or breast-feeding

- lifetime history of psychosis, bipolar disorder, alcohol, medication or drug abuse or dependence; current primary depressive disorder

- lifetime history of epilepsy or other significant disease or disorder

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• d-cycloserine

• placebo

Behavioral:
• cognitive-behaviour therapy

Locations
Country Name City State
United Kingdom Department of Psychiatry, University of Oxford Oxford

Sponsors (2)
Lead Sponsor Collaborator
University of Oxford Medical Research Council

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary self-reported and clinician-rated anxiety and depression measures 6 months
Secondary emotional information processing 1 day
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