Panic Disorder Clinical Trial
OBJECTIVES: I. Determine whether the prevalence of abnormalities on clinical vestibular
(balance) tests is higher in panic disorder with agoraphobia than in uncomplicated panic
disorder and nonpanic anxiety disorder.
II. Determine whether the prevalence of abnormalities on audiological tests of cochlear or
brainstem function is elevated in panic disorder without agoraphobia or nonpanic anxiety
disorder.
III. Determine whether symptom patterns can be identified that are indicative of vestibular
abnormalities in panic disorder.
IV. Determine whether vestibular dysfunction can be induced by psychosomatic mechanisms.
PROTOCOL OUTLINE: Patients are stratified by otoneurological function (panic disorder
without agoraphobia, panic disorder with agoraphobia, anxiety disorder without panic or
agoraphobia-like avoidance, and normal controls).
Patients undergo a psychiatric interview and a structured interview focused on anxiety
disorders. Physical evaluation is completed.
A vestibular evaluation consisting of posturography, rotational testing, and ocular motor
screening battery, and positional and caloric testing is completed on all patients. Patients
then complete an audiological test battery consisting of basic audiological analysis, speech
recognition scores, immittance testing, brainstem evoked response, and determination of
binaural masking level differences.
Control patients also complete a hyperventilation-rotational test.
;
Primary Purpose: Diagnostic
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