Panic Disorder With Agoraphobia Clinical Trial
Official title:
Internet-based Exposure Therapy for Panic Disorder: A Randomized Controlled Pilot Study
The purpose of this study is examine if an internet-based exposure therapy based on inhibitory learning is feasible, acceptable and effective in reducing panic symptoms amongst patients who suffer from panic disorder and agoraphobia.
Trial objectives: Primary objective is to examine if an internet-based exposure therapy based
on inhibitory learning is effective in reducing panic symptoms. The secondary objective is to
study if the protocol is feasible and acceptable. Secondary objective is measured is examined
on 1) number of participants completing the study protocol, 2) participants' satisfaction
with the treatment, 3) therapists' ratings of acceptability. The aim of this study is to
assess the feasibility, and pilot the design and delivery of a RCT that will subsequently
form the framework for a larger RCT to evaluate the effectiveness of an exposure protocol
based on inhibitory learning.
Trial Design: Randomized controlled pilot study with two groups randomly assigned to either
Internet-based exposure therapy based on the principles of inhibitory learning or
Internet-based exposure therapy based on the principles of habituation Duration: Eight weeks
Primary Endpoint: Change in panic symptoms from baseline to Week 8. Efficacy Parameters:
Panic Disorder Severity Scale - Self rated (PDSS-SR) Safety Parameters: Adverse Events is
assessed weekly via the internet. Description of Trial Subjects: Patients > 18 years old with
a PDSS-SR score more than 6 points Number of Subjects: 80
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