Pandemic Influenza Clinical Trial
Official title:
A Phase I/IIa Trial to Evaluate the Safety, Reactogenicity, and Immunogenicity of an H5N1 Virus-Like Particle (VLP) Influenza Vaccine (Recombinant)
Verified date | March 2012 |
Source | Novavax |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Food and Drug Administration |
Study type | Interventional |
This is a Phase I/IIa randomized, double-blind, placebo-controlled study to evaluate the safety, reactogenicity, and immunogenicity of 3 potencies (dosages) of H5N1 VLP vaccine or placebo in healthy adults 18 to 40 years of age.
Status | Completed |
Enrollment | 230 |
Est. completion date | November 2008 |
Est. primary completion date | November 2008 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: 1. Male or female 18 to 40 years of age at the time of the vaccination. 2. Subjects who the investigator believes can and will comply with the requirements of the protocol (e.g., return for follow-up visits and completion of the data collection tool). 3. Available by telephone. 4. Free of obvious health problems as established by medical history and clinical examination before entering the study. 5. If subject is of childbearing potential, she must be abstinent or have used adequate contraceptive precautions (e.g., intrauterine contraceptive device; oral contraceptives or other equivalent hormonal contraception) for 30 days prior to vaccination. She must also have a negative pregnancy test at study entry and must agree to continue such precautions for two months after completion of vaccination. 6. Must provide written, informed consent. Exclusion Criteria: 1. Use of any investigational or non-registered product (drug or vaccine) other than the study vaccine(s) within 30 days preceding the administration of the study vaccine, or planned use during the study period. 2. Has received any other licensed vaccines within 4 weeks prior to enrollment in this study. 3. Has received any influenza vaccine within the prior 12 month period. 4. Has received any investigational vaccine designed for protection against avian influenza. 5. Chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs within six months prior to the administration of the study vaccine. The use of inhaled and nasal steroids will be permitted. 6. Any medically diagnosed or suspected immunodeficient condition based on medical history and physical examination. 7. Administration of immunoglobulins and/or any blood products within the three months preceding the administration of the study vaccine or during the study. 8. Acute disease at the time of enrollment. Acute disease is defined as the presence of a moderate or severe illness with or without fever = 100.5ยบ F. 9. Acute clinically significant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory screening tests. 10. Major congenital defects or serious chronic illness. 11. History of any neurological disorders or seizures, with the exception of febrile seizures during childhood. |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
United States | Healthcare Discoveries, Inc. | San Antonio | Texas |
Lead Sponsor | Collaborator |
---|---|
Novavax |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Safety and reactogenicity of H5N1 VLP Vaccine | 6 months | Yes | |
Secondary | Immunogenicity of H5N1 VLP Influenza vaccine | 6 months | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00976469 -
A/H1N1 Immunogenicity and Safety in Infants, Children and Adolescents
|
Phase 1/Phase 2 | |
Completed |
NCT00971542 -
Immunogenicity, Safety and Tolerability of Two Doses of Adjuvanted and Non-adjuvanted Swine Origin A/H1N1 Monovalent Influenza Vaccine (Egg-Derived) in Healthy Subjects From 6 Months to 17 Years of Age
|
Phase 3 | |
Completed |
NCT00535665 -
Safety and Immunogenicity of an Inactivated Pandemic Influenza Vaccine
|
Phase 2 | |
Completed |
NCT00950456 -
Observational Study to Assess Safety of H1N1 Pandemic Influenza Vaccine
|
N/A | |
Completed |
NCT00908687 -
A/H5N1/LT Dose Ranging Study
|
Phase 2 | |
Completed |
NCT00783926 -
Phase 1 Study of a H5N1 Influenza Vaccine (Reverse Genetic Reassortant)
|
Phase 1 | |
Recruiting |
NCT06046092 -
H7HLAII DNA Influenza Vaccine
|
Phase 1 | |
Completed |
NCT01640691 -
Immunogenicity and Safety of Pandemic Influenza Vaccine in Healthy Adults
|
Phase 1/Phase 2 | |
Completed |
NCT01053143 -
Study of Swine-Origin A/H1N1 Influenza Non-Adjuvanted Vaccine in Healthy Adults in India
|
Phase 3 | |
Completed |
NCT00457509 -
Safety and Immunogenicity of H5N1 Adjuvanted, Inactivated, Split-Virion Pandemic Influenza Vaccine in Healthy Adults
|
Phase 1 | |
Completed |
NCT00660257 -
Safety and Immunogenicity of Booster Dose of An Inactivated,Adjuvanted Whole-Virion Pandemic Influenza(H5N1)Vaccine
|
Phase 1 | |
Completed |
NCT00970177 -
Immunogenicity, Safety and Tolerability of Two Doses of Adjuvanted and Non-adjuvanted Swine Origin A/H1N1 Monovalent Influenza Vaccine in Healthy Subjects 18 or More Years of Age
|
Phase 3 | |
Completed |
NCT00971100 -
Immunogenicity, Safety and Tolerability of Two Doses of Adjuvanted and Non-adjuvanted Swine Origin A/H1N1 Monovalent Influenza Vaccine in Healthy Subjects From 6 Months to 17 Years of Age
|
Phase 3 | |
Completed |
NCT00971906 -
Immunogenicity, Safety and Tolerability of Two Doses of Adjuvanted and Non-adjuvanted Swine Origin A/H1N1 Monovalent Influenza Vaccine in Healthy Subjects 18 or More Years of Age
|
Phase 3 | |
Completed |
NCT00959465 -
A/H1N1 Immunogenicity and Safety in Adults
|
Phase 1/Phase 2 | |
Completed |
NCT00532792 -
A/H5N1 Dose Ranging Study With Adjuvant Patch
|
Phase 1 | |
Withdrawn |
NCT00640302 -
A Prospective Study to Examine the Effectiveness and Safety of Neuraminidase Inhibitors in Index Cases With Presumed Pandemic Influenza
|
N/A | |
Withdrawn |
NCT00640874 -
A Prospective Study to Examine the Effectiveness and Safety of Antivirals in Volunteers Who Receive Short-term Prophylaxis Against Pandemic Influenza
|
N/A | |
Withdrawn |
NCT00640211 -
A Prospective Study to Examine the Effectiveness and Safety of Neuraminidase Inhibitors in Volunteers Who Receive Long-term Prophylaxis Against Pandemic Influenza: PIPET B
|
N/A |