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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00519389
Other study ID # H5N1 VLP-1
Secondary ID
Status Completed
Phase Phase 1/Phase 2
First received August 20, 2007
Last updated June 12, 2013
Start date July 2007
Est. completion date November 2008

Study information

Verified date March 2012
Source Novavax
Contact n/a
Is FDA regulated No
Health authority United States: Food and Drug Administration
Study type Interventional

Clinical Trial Summary

This is a Phase I/IIa randomized, double-blind, placebo-controlled study to evaluate the safety, reactogenicity, and immunogenicity of 3 potencies (dosages) of H5N1 VLP vaccine or placebo in healthy adults 18 to 40 years of age.


Recruitment information / eligibility

Status Completed
Enrollment 230
Est. completion date November 2008
Est. primary completion date November 2008
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria:

1. Male or female 18 to 40 years of age at the time of the vaccination.

2. Subjects who the investigator believes can and will comply with the requirements of the protocol (e.g., return for follow-up visits and completion of the data collection tool).

3. Available by telephone.

4. Free of obvious health problems as established by medical history and clinical examination before entering the study.

5. If subject is of childbearing potential, she must be abstinent or have used adequate contraceptive precautions (e.g., intrauterine contraceptive device; oral contraceptives or other equivalent hormonal contraception) for 30 days prior to vaccination. She must also have a negative pregnancy test at study entry and must agree to continue such precautions for two months after completion of vaccination.

6. Must provide written, informed consent.

Exclusion Criteria:

1. Use of any investigational or non-registered product (drug or vaccine) other than the study vaccine(s) within 30 days preceding the administration of the study vaccine, or planned use during the study period.

2. Has received any other licensed vaccines within 4 weeks prior to enrollment in this study.

3. Has received any influenza vaccine within the prior 12 month period.

4. Has received any investigational vaccine designed for protection against avian influenza.

5. Chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs within six months prior to the administration of the study vaccine. The use of inhaled and nasal steroids will be permitted.

6. Any medically diagnosed or suspected immunodeficient condition based on medical history and physical examination.

7. Administration of immunoglobulins and/or any blood products within the three months preceding the administration of the study vaccine or during the study.

8. Acute disease at the time of enrollment. Acute disease is defined as the presence of a moderate or severe illness with or without fever = 100.5ยบ F.

9. Acute clinically significant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory screening tests.

10. Major congenital defects or serious chronic illness.

11. History of any neurological disorders or seizures, with the exception of febrile seizures during childhood.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention


Related Conditions & MeSH terms


Intervention

Biological:
H5N1 VLP Vaccine
Two doses - Day 0 & Day 28
Placebo
Two doses - Day 0 & Day 28

Locations

Country Name City State
United States Healthcare Discoveries, Inc. San Antonio Texas

Sponsors (1)

Lead Sponsor Collaborator
Novavax

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Safety and reactogenicity of H5N1 VLP Vaccine 6 months Yes
Secondary Immunogenicity of H5N1 VLP Influenza vaccine 6 months No
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