Management of Childhood Pancytopenia

Pancytopenia Clinical Trial

Official title:

Management of Childhood Pancytopenia in Heamatology Unit in Assiut University Hospital

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03521947
• Other study ID #: MCP
• Status: Not yet recruiting
• Start date: June 1, 2018
• Est. completion date: December 1, 2019

Study information

• Verified date: May 2018
• Source: Assiut University
• Contact: Ahmed Gadelrab Askr, Professor
• Phone: 01114064050
• Email: ahmed.mohamed35[@]med.au.edu.eg
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Pancytopenia is an important hematologic Problem.it is a decrease in all three cellular elements of peripheral blood leading to aneamia, leucopenia and thrombocytopenia.

Description:

Pancytopenia usually presents with symptoms of bone marrow failure such as pallor, dysnea, brusing and increased tendency to infections.

The incidence of various disorders causing pancytopenia varies according to Geographical distribution and genetic mutations. It can result from :

• Failure of production of hematopoietic progenitors in bone marrow as in aplastic aneamia.

• Bone marrow infiltration by malignant cells as in acute leukemia.

• Antibodies mediated bone marrow suppression as in systemic lupus.

• Ineffective hematopoiesis and dysplasia as in nutrition deficiency.

• Peripheral sequestration of blood cells in over active reticuloendothelial system as in hypersplenism.

Pancytopenia is not a disease entity but a triad of findings that may result from primary or secondary bone marrow involvement.

Bone marrow aspiration and biopsy evaluation along with clinical correlation are important to evaluate the causes of pancytopenia and plan further investigations and treatment.

Pancytopenia can result from damage to bone marrow evidanced by low reticulocyte count, or increased destruction of the peripheral blood with increased reticulocyte count.

Bone marrow examination is a simple and safe invasive procedure for evaluating the causes of pancytopenia.

The hypoplastic marrow which occurs in 2% of pediatrics acute lymphoblastic leukemia may be misdiagnosed as aplastic aneamia.

Studies done have shown leukemia to be the second most common cause of pancytopenia in pediatrics, marginally behind aplastic aneamia.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 25
• Est. completion date: December 1, 2019
• Est. primary completion date: June 1, 2019
• Gender: All
• Age group: N/A to 18 Years

Eligibility

Inclusion Criteria:

• All childrens and adolescents suffering from pancytopenia attending heamatology unit of pediatric department Assiut University Hospital will be included.

Exclusion Criteria:

• childrens and adolescents suffering from pancytopenia due to malignancy.

Related Conditions & MeSH terms

• Pancytopenia

Intervention

Diagnostic Test:
• Complete blood picture
Iaboratory investigation

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (4)

Al-Khalisi, K.A,Al-zubaidy, A. S and Rhaima. M. 2011.Pancytopenia adult patients atBaghdad Teatching Hospital. The Iraqi postgraduate medical journals, 10,441-448

Desalphine M, Bagga PK, Gupta PK, Kataria AS. To evaluate the role of bone marrow aspiration and bone marrow biopsy in pancytopenia. J Clin Diagn Res. 2014 Nov;8(11):FC11-5. doi: 10.7860/JCDR/2014/9042.5169. Epub 2014 Nov 20. — View Citation

Hayat,A.S, Khan,A.H,GH and Shaikh, N . (2014). Pancytopenia :study for clinical features and Etiological pattern at a tertiary care settings in Abbottabad.The professional medical journal, 21,060-065.

Raja S, Suman FR, Scott JX, Latha MS, Rajenderan A, Ethican A. Pancytopenia - (?) An obstacle in the diagnosis and outcome of pediatric acute lymphoblastic leukemia. South Asian J Cancer. 2015 Apr-Jun;4(2):68-71. doi: 10.4103/2278-330X.155648. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Availability	Bone marrow examination for all cases [evaluate the causes of pancytopenia and plan further investigations and treatment.]	One year
Secondary	Modification	Guidelines for management of pancytopenia modified or not? [Strategy of blood elements transfusion in treatment]	One year