Optimal Timing of Endoscopic Intervention in the Treatment of Chronic

Status Not yet recruiting

Clinical Trial Summary

This study aims to determine the optimal timing of endoscopic intervention after extracorporeal shock wave lithotripsy(ESWL) of chronic pancreatitis with pancreatic stones.

Clinical Trial Description

Chronic pancreatitis（CP）is a chronic progressive fibro-inflammatory disease of the pancreas induced by a wide range of factors including genetic and environmental elements, with recurrent abdominal pain and pancreatic secretion insufficiency as its major clinical signs. Chronic pancreatitis is not only a tough disease of the gastrointestinal system but also a worldwide medical problem. At present, the MESS (medicine-extracorporeal shock wave lithotripsy-endoscopic retrograde cholangiopancreatography-surgery）formed by changhai hospital in CP diagnosis and treatment is gradually becoming mature, and the clinical effect of this system is obvious. However, there are still some difficulties and knowledge gaps in the clinical treatment of CP. Currently, it is recommended by both domestic and foreign guidelines that ERCP combined with ESWL as the first-line treatment pattern for patients with chronic pancreatitis associate pain. It has previously been observed that ERCP performed less than 2 days after ESWL may be more likely to fail, possibly owing to ESWL-induced edema. However, there is no high-quality research to demonstrate how to choose the most optimal timing of ERCP after ESWL for patients with indications for endoscopic treatment. This prospective, randomized controlled research has therefore aimed to determine the most optimal timing of ERCP after ESWL. Patients with painful chronic pancreatitis and pancreatic stones larger than 5 mm in diameter will be randomly and equally assigned to three groups, which are divided according to the time interval between ESWL and ERCP, including <12 hours subgroup, 12~36 hours subgroup and >36 hours subgroup. The cannulation success rate and stone clearance rate of the pancreatic duct will be assessed in each group to explore the most appropriate timing of ERCP, and then provide an important reference basis for the clinical treatment of chronic pancreatitis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05270434
Study type	Interventional
Source	Changhai Hospital
Contact	Zhuan Liao
Phone	13061921980
Email	liaozhuan@smmu.edu.cn
Status	Not yet recruiting
Phase	N/A
Start date	March 1, 2022
Completion date	February 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT05326542` - Comparison of Efficacy of ESWL and Laser Lithotripsy in Chronic Pancreatitis With ERCP	N/A
Completed	`NCT01551511` - Δ9-THC (Namisol®) in Chronic Pancreatitis Patients Suffering From Persistent Abdominal Pain	Phase 2
Completed	`NCT01731821` - Nonstented Stump-closed vs Duct-to-Mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy	Phase 3
Active, not recruiting	`NCT05095831` - EUS Shear Wave for Solid Pancreatic Lesions.
Completed	`NCT03173118` - Elastography in the Diagnosis of Chronic Pancreatitis	N/A
Terminated	`NCT01318590` - Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis	Phase 3
Recruiting	`NCT05772234` - Aggressive Intravenous Hydration With Lactated Ringer's Solution for Prevention of Post-ESWL Pancreatitis	N/A
Recruiting	`NCT04131010` - Digital Catheter Based Pancreatoscopy (SpyGlassDS) for the Management of Symptomatic Pancreatic Duct Stones in Selected Patients With Chronic Pancreatitis	N/A
Terminated	`NCT00359320` - A Randomized Trial of Two Surgical Techniques for Pancreaticojejunostomy in Patients Undergoing Pancreaticoduodenectomy	N/A
Completed	`NCT02940067` - Enhancing Fitness Before Pancreatic Surgery	N/A
Recruiting	`NCT05261997` - Endotherapy for Painless Chronic Pancreatitis	N/A
Completed	`NCT03672422` - Pediatric Longitudinal Cohort Study of Chronic Pancreatitis
Enrolling by invitation	`NCT05287737` - Clinical Outcome After Total Pancreatectomy With Islet Autotransplantation
Not yet recruiting	`NCT06426160` - Tocilizumab for Painful Chronic Pancreatitis	Phase 2
Enrolling by invitation	`NCT05289362` - Comparison of Efficacy of Basket and Balloon in the Removal of Pancreatic Duct Stones in Chronic Pancreatitis Under ERCP	N/A
Not yet recruiting	`NCT04760847` - Intermittent Fasting for Pancreatitis	N/A
Enrolling by invitation	`NCT03228095` - Volatiles in Breath and Headspace Analysis - Diagnostic Markers
Completed	`NCT00956839` - Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis	Phase 4
Completed	`NCT00676702` - A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI)	Phase 1
Recruiting	`NCT04672642` - Evaluation of the SpyGlass DS for Detection of Residual Pancreatic Calculations	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Optimal Timing of Endoscopic Intervention in the Treatment of Chronic Pancreatitis. — TEST

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms