Pancreatitis, Acute Necrotizing Clinical Trial
Official title:
Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following
Cytokines such as such as TNF-a, IL-1, IL-6 correlate with the severity of pancreatitis.Neuroendocrine pathways, such as the sympathetic nervous system or parasympathetic nervous system, in turn, have some impact on the immune systems, through a-2 adrenoreceptor stimulation or the cholinergic anti-inflammatory pathway. The investigators aim to use Dexmedetomidine Hydrochloride to decrease the activity of sympathetic nervous system, thus relieve inflammation response.
Infected pancreatic necrosis (IPN) and multiple organ dysfunction syndrome (MODS) are major
complications of acute pancreatitis which determine disease severity and outcome.It is
concluded that systemic inflammation in SAP characterized by the endocrine release of
different cytokines, such as TNF-a, IL-1, IL-6 and many others. These cytokines correlate
with the severity of pancreatitis.
Neuroendocrine pathways, such as the sympathetic nervous system or parasympathetic nervous
system, in turn, have some impact on the immune systems, through a-2 adrenoreceptor
stimulation or the cholinergic anti-inflammatory pathway. Dexmedetomidine Hydrochloride is a
high selected a-2 adrenoreceptor agonists.Some studies have shown that Dexmedetomidine
Hydrochloride could improve the outcome of sepsis patients and decrease the development of
organ failure.
The investigators aim to use Dexmedetomidine Hydrochloride to decrease the activity of
sympathetic nervous system,thus relieve inflammation response.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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