Pancreatic Fistula Clinical Trial
Official title:
Clinically Relevant Postoperative Pancreatic Fistula After Pancreaticoduodenectomy for Periampullary Cancer and Risk Factors: A Prospective Multicenter Study
Patients who are diagnosed with periampullary cancer will be performed pancreaticoduodenectomy with 3 types of pancreatic-jejunal anastomosis reconstructions. The investigator will analysis the complication of pancreatic fistula about: the clinical symptoms, laboratory test changing, intra-operative morphology, the risk factors
This study will conduct at two centers at the same time: University of Medicine and Pharmacy Center and Cho Ray Hospital. The patients will be consulted to participate to this research from September, 2021 to April, 2023. Plan for conducting study: - The investigator consults and gets consensus form of the patient with periampullary cancer. - The patient will be prepared for pancreaticoduodenectomy: pre-operative laboratory test, pre-operative biliary drainage, anesthetic checking. - The investigator collected intr-operative data, include type of pancreatic-duodenal reconstruction, type of pancreatic duct's drainage, quantity of blood loss and blood transfusion. - The investor follows post-operative period. - If there are pancreatic fistula appear, the investigator will collect the clinical signs, laboratory test changing, re-operative morphology. - The investigator analysis the risk factors of pancreatic fistula. Data analysis: - To determine the incidence of pancreatic fistula, the morphology of pancreatic fistula, descriptive statistics will be used. - To determine the risk factors of pancreatic fistula, logistic regression will be used. Sample size: - The investigator plans to collect 145 patients in the research period. Plan for missing data: - Any case that miss information will be removed from the study. ;
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