Pancreatic Fistula Clinical Trial
Official title:
Risk Factors for Pancreaticojejunostomy Leakage Following Whipple Operation
NCT number | NCT04798560 |
Other study ID # | 8515/31-05-2019 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | October 10, 2018 |
Est. completion date | May 2022 |
Pancreatic cancer is an aggresive type of cancer with poor mean survival rates despite improvements in chemotherapy regimens and advances in surgical techniques. Surgery is the only therapeutic option with an intend to treat. Pancreaticoduodenectomy is indicated for malignancy in the pancreatic head as well as other periampullary tumors. One of the most fatal complications after Whipple operation is postoperative pancreatic fistula as a result of pancreatojejunostomy leakage. Various risk factors for pancreatojejunostomy leakage have been proposed, while there are others less studied.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | May 2022 |
Est. primary completion date | April 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: 1. Age more than or equal to 18 years 2. periampullary pathologies (benign or malignant) with indication for panceaticoduodenectomy 3. Pancreaticojejunal anastomosis performed 4. Curative resection 5. Signed informed consent form - Exclusion Criteria: 1. Age less than 18 years old 2. One stage total pancreatectomy 3. External wirsungostomy without pancreaticojejunal anastomosis 4. Subtotal pancreatectomy without pancreaticojejunal anastomosis 5. Left pancreatectomies 6. Intraoperatively findings of unresectable tumors 7. Pregnancy 8. Concurrent participation in other study(ies) |
Country | Name | City | State |
---|---|---|---|
Greece | 1st Propaedeutic Department of Surgery, Hippokrateion General Hospital | Athens | Attiki |
Lead Sponsor | Collaborator |
---|---|
Dimitrios Vouros |
Greece,
Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, Neoptolemos J, Sarr M, Traverso W, Buchler M; International Study Group on Pancreatic Fistula Definition. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery. 2005 Jul;138(1):8-13. Review. — View Citation
Bassi C, Marchegiani G, Dervenis C, Sarr M, Abu Hilal M, Adham M, Allen P, Andersson R, Asbun HJ, Besselink MG, Conlon K, Del Chiaro M, Falconi M, Fernandez-Cruz L, Fernandez-Del Castillo C, Fingerhut A, Friess H, Gouma DJ, Hackert T, Izbicki J, Lillemoe KD, Neoptolemos JP, Olah A, Schulick R, Shrikhande SV, Takada T, Takaori K, Traverso W, Vollmer CR, Wolfgang CL, Yeo CJ, Salvia R, Buchler M; International Study Group on Pancreatic Surgery (ISGPS). The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After. Surgery. 2017 Mar;161(3):584-591. doi: 10.1016/j.surg.2016.11.014. Epub 2016 Dec 28. Review. — View Citation
Cullen JJ, Sarr MG, Ilstrup DM. Pancreatic anastomotic leak after pancreaticoduodenectomy: incidence, significance, and management. Am J Surg. 1994 Oct;168(4):295-8. — View Citation
Denbo JW, Orr WS, Zarzaur BL, Behrman SW. Toward defining grade C pancreatic fistula following pancreaticoduodenectomy: incidence, risk factors, management and outcome. HPB (Oxford). 2012 Sep;14(9):589-93. doi: 10.1111/j.1477-2574.2012.00486.x. Epub 2012 May 28. Review. — View Citation
Nahm CB, Connor SJ, Samra JS, Mittal A. Postoperative pancreatic fistula: a review of traditional and emerging concepts. Clin Exp Gastroenterol. 2018 Mar 15;11:105-118. doi: 10.2147/CEG.S120217. eCollection 2018. Review. — View Citation
Ryan DP, Hong TS, Bardeesy N. Pancreatic adenocarcinoma. N Engl J Med. 2014 Sep 11;371(11):1039-49. doi: 10.1056/NEJMra1404198. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Development of Postoperative pancreatic fistula after pancreaticoduodenectomy | Following pancreaticoduodenectomy, patients are observed for developing POPF according to ISGPF definition | 30 days | |
Secondary | Mortality | Mortality rates expressed in % of the patients | 30 days | |
Secondary | Morbidity | Morbidity rates expressed in % of the patients | 30 days | |
Secondary | Postoperative complications | Complications classified according to Clavien-Dindo Classification taking measures from I up to V | 30 days | |
Secondary | Duration of Hospital stay | Duration of Hospital stay in days | 60 days | |
Secondary | Readmission | Readmission rates expressed in % of the patients | 30 days | |
Secondary | Reoperation | Reoperation rates expressed in % of the patients | 30 days | |
Secondary | Overall survival | Estimation of days from operation until death expressed in days | 2 years |
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