Pancreatic Fistula Clinical Trial
Official title:
Role of Preoperative Multislice Computed Tomography to Predict the Risk of Pancreatic Fistula After Whipple's Operation.
Preoperative assessment of visceral fat volume(VFV),total fat volume(TFV),pancreas/spleen density ratio and pancreatic duct diameter by multislice computed tomography abdomen to predict the risk of pancreatic fistula after Whipple's operation.
pancreatic cancer has ranked the 11th most common cancer in the world and seventh leading
cause of cancer-related deaths worldwide. Worldwide incidence and mortality of pancreatic
cancer correlate with increasing age and is slightly more common in men than in women(1).
There are many risk factors for pancreatic cancer, such as age, tobacco smoking, heavy
alcohol consumption, obesity, low physical activity, chronic pancreatitis, long-standing type
2 diabetes, ABO blood type, and family history(2).
Pancreatic cancer is mainly divided into two types of pancreatic cancer: pancreatic
adenocarcinoma, which is the most common (85% of cases) arising in exocrine glands of the
pancreas, and pancreatic neuroendocrine tumor (PanNET), which is less common (less than 5%)
and occurs in the endocrine tissue of the pancreas.Signs and symptoms of pancreatic cancer
often don't occur until the disease is advanced(3).
Upon progression of the tumor, it manifests as a gradual onset of non-specific symptoms
including jaundice, weight loss, light-colored stools, abdominal pain and fatigue(4).
Treatment for pancreatic cancer depends on the stage and location of the cancer as well as on
your overall health and personal preferences. Surgery, chemotherapy and radiotherapy are
traditionally used to extend survival and/or relieve the patients' symptoms. However, for
advanced-stage cancer cases, there is still no definite cure(5).
Postoperative pancreatic fistula (POPF) remains one of the most frequent and threatening
complication after pancreatoduodenectomy (PD). The occurrence ranges from 10% to 30%(6).
Depending on its severity, it may be responsible for distant organ dysfunction and subsequent
mortality, prolonged length of in-hospital stay, and increased health care costs(7).
Both prevention and treatment of POPF are challenging. Among the potential strategies to
reduce the incidence and the severity of POPF, different surgical techniques(8) have been
proposed along with the perioperative inhibition of exocrine pancreatic secretion(9).
An additional key factor to improve patient management may be to find reliable means of
calculating and predicting the risk of POPF. The ability of anticipating the risk of POPF
before surgery based on peculiar patient features might establish a more customized
preoperative program for patients with high risk of fistula, potentially excluding subjects
with elevated risk from surgical resection or to set up protocols for a strict and early
detection of warning clinical scenario .Previous studies and reviews described different
variables correlated to the occurrence of POPF, in particular, patient characteristics such
as American Society of Anesthesiology score, body mass index, age, malnutrition, muscle
cachexia, medical history and morbidities(10)(11)and intraoperative findings, that is, small
Wirsung duct diameter, soft pancreatic texture, and estimated blood loss(12).
The multivariate analysis revealed that a visceral fat volume(VFV) >2334 cm3,total fat
volume(TFV) >4408 cm3, pancreas/spleen density ratio <0.707, and pancreatic duct diameter
<5mm were predictive of POPF(13).
Also baseline radiological findings, such as fat distribution, radiological characteristics
of abdominal skeletal muscles, estimated pancreatic remnant volume, and pathway of the
enhancement attenuation have been correlated with the risk of complication development and
POPF, but with inconsistent results(14)(15).
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