Pancreatic Cancer Clinical Trial
Official title:
Early Detection of Anastomotic Leakage by Microdialysis Catheters: An Observational Study on Pancreaticoduodenectomy
Anastomotic leakage of the pancreatojejunostomy is often discovered with considerable delay, causing severe peritonitis, hemorrhage due to erosion of vessels, sepsis, and death. Microdialysis catheters can detect focal inflammation and ischemia, and has a potential for early detection of anastomotic leakage. This observational study will examine if monitoring with microdialysis catheters can detect anastomotic leakage after pancreaticoduodenectomy earlier than current standard of care.
Pancreaticoduodenectomy (Whipple´s procedure) offers the only potential cure for patients
with tumor in the head of the pancreas, bile duct or periampullary region. This procedure is
associated with high perioperative and postoperative mortality and morbidity. Postoperative
pancreatic fistulae (POPF) is the most feared complication, and is often discovered with
significant delay resulting in development of organ dysfunction and sepsis. Current standard
for clinical detection of POPF is limited and nonspecific.
Microdialysis catheters allow bedside measurements of metabolism such as lactate, pyruvate,
glucose and glycerol. The method has a high sensitivity and specificity in detecting
complications in several types of abdominal surgery. However, microdialysis used after
pancreaticoduodenectomy is not well documented. This observational study examine if
monitoring with microdialysis catheters can detect anastomotic leakage after
pancreaticoduodenectomy earlier than current standard of care.
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