Pancreatic Ductal Adenocarcinoma Clinical Trial
Official title:
An Open-label, Dose-finding, Phase Ib Study to Assess the Safety, Tolerability of JPI-547, a Dual Inhibitor of PARP/Tankyrase, in Combination With Modified FOLFIRINOX (mFOLFIRINOX) or Gemcitabine-nab-paclitaxel (GemAbraxne) in Patients With Locally Advanced and Metastatic Pancreatic Cancer
The purpose of this study is to assess the safety, tolerability of JPI-547 in combination with modified FOLFIRINOX (mFOLFIRINOX) or Gemcitabine-nab-paclitaxel (GemAbraxne) in patients with locally advanced and metastatic pancreatic cancer
In combination with JPI-547 and chemotherapy in patients with locally advanced/metastatic pancreatic cancer, Primary Objectives - To determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D). - To select the optimal combination chemotherapy based on the safety profile. Secondary Objectives - To assess the safety and toxicity. - To evaluate anti-tumor activity. ;
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