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Ivosidenib + mFOLFIRINOX in Patients With Resectable Pancreatic Adenocarcinoma

Pancreatic Ductal Adenocarcinoma Clinical Trial

Official title:
A Phase I, Single-Center, Open-Label, Dose De-escalation and Expansion Study Ivosidenib + mFOLFIRINOX in Patients With Resectable Pancreatic Adenocarcinoma

Clinical Trial Summary

This study is a single-arm, phase I trial, up to 16 participants with resectable PDA. The study will examine the efficacy of the mutant IDH1 inhibitor ivosidenib, in conjunction with standard-of-care mFOLFIRINOX in the neoadjuvant setting.

Clinical Trial Description

Currently, the standard of care treatment for resectable PDA is surgical resection followed by adjuvant chemotherapy. The use of mFOLFIRINOX in this setting has extended survival significantly. Giving ivosidenibwith mFOLFIRINOXmay work better than treating participants with mFOLFIRINOX alone. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05209074
Study type Interventional
Source Case Comprehensive Cancer Center
Contact David Bajor, MD
Phone 800-641-2422
Email ctureferral@uhhospitals.org
Status Recruiting
Phase Phase 1
Start date September 8, 2022
Completion date October 15, 2024
View Details
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