Mesenteric Approach vs. Conventional Approach for Pancreatic Cancer

Pancreatic Ductal Adenocarcinoma Clinical Trial

Official title: Mesenteric Approach vs. Conventional Approach for Pancreatic Cancer During Pancreaticoduodenectomy (MAPLE-PD Trial)

Status Not yet recruiting

Clinical Trial Summary

The aim of this study is to evaluate the advantage of mesenteric approach during pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC). The design of this study is multicenter randomized clinical trial, comparing oncological and surgical outcomes between mesenteric approach and conventional approach during PD for PDAC.

Clinical Trial Description

Mesenteric approach starts from dissection of lymph nodes around the superior mesenteric artery (SMA) and finally performs Kocher's maneuver during PD. The aims of this approach are 1) decrease of intraoperative blood loss volume, 2) increase of R0 rate, and 3) prevention of squeezing cancer cells out into the vessels. However, there have been no evidence of the efficacy of this procedure. Therefore, the aim of this study is to evaluate the efficacy of mesenteric approach during PD for PDAC, by multicenter randomized clinical trial comparing oncological and surgical outcomes between mesenteric approach and conventional approach during PD for PDAC. ;

Related Conditions & MeSH terms

• Adenocarcinoma
• Mesenteric Approach
• Pancreatic Ductal Adenocarcinoma
• Pancreatic Neoplasms
• Pancreaticoduodenectomy

• NCT number: NCT03317886
• Study type: Interventional
• Source: Wakayama Medical University
• Contact: Seiko Hirono, M.D.,PhD
• Phone: +81-73-441-0613
• Email: seiko-h@wakayama-med.ac.jp
• Status: Not yet recruiting
• Phase: Phase 3
• Start date: December 1, 2017
• Completion date: November 30, 2021