Clinical Trials Logo
  1. Home
  2. Pancreatic Cyst
  3. NCT05572788

Rectal Indomethacin to Prevent Acute Pancreatitis in EUS-FNA of Pancreatic Cysts

Pancreatic Cyst Clinical Trial

Official title:
Randomized Trial of Rectal Indomethacin to Prevent Acute Pancreatitis in Patients Undergoing Endoscopic Ultrasound-guided Fine Needle Aspiration of Pancreatic Cysts

Clinical Trial Summary

The aim of this randomized trial is to compare the rate of post-procedure pancreatitis in patients undergoing EUS-FNA of pancreatic cysts; patients will receive either a single dose of indomethacin or placebo administered rectally, during EUS-FNA.

Clinical Trial Description

Pancreatic cysts are pre-malignant lesions and are being increasingly diagnosed on cross-sectional imaging. Endoscopic ultrasound (EUS) is performed to further evaluate pancreatic cysts, and fine needle aspiration (FNA) is conducted to obtain a sample of the cystic fluid for analysis and examination for malignant cells. Acute pancreatitis is a complication of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of pancreatic cysts, which can lead to significant morbidity and substantial health care costs. The aim of this randomized trial is to compare the rate of post-procedure pancreatitis in patients undergoing EUS-FNA of pancreatic cysts; patients will receive either a single dose of indomethacin or placebo administered rectally, during EUS-FNA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05572788
Study type Interventional
Source Orlando Health, Inc.
Contact Barbara J Broome
Phone 321-841-7031
Email barbara.broome@orlandohealth.com
Status Recruiting
Phase N/A
Start date September 26, 2022
Completion date December 2025
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT06320990 - Chemoprevention With Tamoxifen in Pre-Invasive Pancreas Mucinous Cystic Neoplasms Not Undergoing Immediate Resection Phase 1
Completed NCT01770405 - Clinical Registry of nCLE in Masses and Cystic Tumors of the Pancreas, Lymph Nodes, Submucosal Lesions of the GI Tract N/A
Completed NCT01643460 - Endoscopic Ultrasound (EUS)-Guided Ablation of Pancreatic Cysts N/A
Recruiting NCT03260842 - Bio-Repository of High Risk Cohorts for the Early Detection of Pancreas Cancer
Recruiting NCT04291651 - UCSF PANC Cyst Registry
Recruiting NCT05692596 - The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics
Recruiting NCT03334708 - A Study of Blood Based Biomarkers for Pancreas Adenocarcinoma
Recruiting NCT04140435 - EUS-guided Through-the-needle Microforceps Biopsy Outcomes
Terminated NCT00550108 - Management of Incidentally Discovered Pancreatic Cysts Phase 3
Recruiting NCT03492151 - Confocal Laser Endomicroscopy as an Imaging Biomarker for the Diagnosis of Pancreatic Cystic Lesions
Completed NCT03169842 - Cyst Fluid Glucose for On-site Diagnosis of Mucinous Pancreatic Cysts N/A
Recruiting NCT04404101 - Evaluation of Pancreatic Cystic Lesions Via EUS-guided Fine Needle Aspiration With and Without Micro Forceps Biopsies N/A
Recruiting NCT06305728 - A Study of Early Cancer Detection in People at High Risk of Developing Pancreatic Ductal Adenocarcinoma (PDAC)
Recruiting NCT06340620 - EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope N/A
Recruiting NCT02343692 - A Phase II Multicentre Trial of Endoscopic Ultrasound Guided Radiofrequency Ablation of Cystic Tumours of the Pancreas N/A
Recruiting NCT02775461 - Pancreas Registry and High Risk Registry
Active, not recruiting NCT01563133 - Clinical Evaluation Of Needle-based Confocal Laser Endomicroscopy in The Lymph Nodes Along With Masses and Cystic Tumors of the Pancreas N/A
Completed NCT00222898 - Cancer Detection in Pancreatic Cysts N/A
Not yet recruiting NCT06276764 - The LINFU® U.S. Registry in Patients With IPMN (Intraductal Papillary Mucinous Neoplasm of the Pancreas)
Completed NCT03740360 - Contrast Enhanced Ultrasound and Molecular Analysis in the Diagnosis of Pancreatic Cyst