Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer

Pancreatic Carcinoma Clinical Trial

Official title:
Pilot Study of Oral Cryotherapy vs. Oral Cryotherapy Plus Acupuncture and Acupressure to Decrease Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy for GI Cancers

Status Active, not recruiting

Clinical Trial Summary

This phase II trial investigates how well oral cryotherapy plus acupressure and acupuncture compared with oral cryotherapy alone work in decreasing chemotherapy-induced peripheral neuropathy in patients with gastrointestinal cancer who are receiving oxaliplatin-based chemotherapy. Acupressure is the application of pressure or localized massage to specific sites on the body to control symptoms such as pain or nausea. Acupuncture is the technique of inserting thin needles through the skin at specific points on the body to control pain and other symptoms. Cryotherapy uses cold temperature such as oral ice chips to prevent abnormally increased pain sensation. Giving oral cryotherapy with acupressure and acupuncture may work better in decreasing chemotherapy-induced peripheral neuropathy from oxaliplatin-based chemotherapy in patients with gastrointestinal cancer compared to oral cryotherapy alone.

Clinical Trial Description

OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients undergo acupuncture during chemotherapy infusion on day 1 and fluorouracil pump disconnect on day 3 of each biweekly chemotherapy infusion over 12 weeks. Patients also undergo self-administered acupressure over 11 minutes daily for 12 weeks and undergo standard of care oral cryotherapy. ARM II: Patients undergo standard of care oral cryotherapy. ;

Study Design

Related Conditions & MeSH terms

Anal Carcinoma
Appendix Carcinoma
Carcinoma
Colon Carcinoma
Digestive System Carcinoma
Digestive System Neoplasms
Digestive System Neuroendocrine Tumor
Esophageal Carcinoma
Esophageal Neoplasms
Gastric Carcinoma
Gastrointestinal Neoplasms
Liver and Intrahepatic Bile Duct Carcinoma
Malignant Digestive System Neoplasm
Neuroendocrine Tumors
Pancreatic Carcinoma
Pancreatic Neoplasms
Pancreatic Neuroendocrine Tumor
Peripheral Nervous System Diseases
Rectal Carcinoma
Small Intestinal Carcinoma
Stomach Neoplasms

Clinical Trial Details

NCT number	NCT04505553
Study type	Interventional
Source	University of Washington
Contact
Status	Active, not recruiting
Phase	Phase 2
Start date	June 1, 2021
Completion date	September 30, 2024

View Details

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