Pancreatic Carcinoma Clinical Trial
Official title:
L-Carnitine in the Palliative Treatment of Advanced Pancreatic Cancer (CARPAN): a Prospective, Randomised, Placebo Controlled, Double Blinded, Multicentre Trial
The study investigated the role of L-Carnitine supplementation on proinflammatory immune response, malnutrition, cancer cachexia and cancer related fatigue in advanced and inoperable pancreatic cancer, UICC Stage IV .
Pancreatic cancer has the lowest 5-year survival rate of any cancer and ranks as the fourth
leading cause of cancer death world wide. Several metabolic changes are present in the whole
body in case of cancer so the investigators conducted a placebo controlled, double blinded,
randomized, prospective and multicentre study to investigate, whether L-Carnitine
supplementation may have an impact on malnutrition, cancer cachexia and cancer related
fatigue in advanced pancreatic cancer.
Study drug: L-Carnitine 4g per day (vers) Placebo Study design: A multi-centre, double
blind, and placebo-controlled, randomised, parallel group study
Patient population: Patients with advanced pancreatic carcinoma Number of patients: Total of
90 patients in two equal groups number of centres: 4 (Greifswald, Magdeburg,
Berlin,Heidelberg,all Germany) Duration of dosing: 12 weeks
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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