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Oncolytic Virus Plus PD-1 Inhibitor to Patients With Advanced Pancreatic Cancer — PTCA199-8  

Pancreatic Cancer Clinical Trial

Official title:
Oncolytic Virus Plus PD-1 Inhibitor to Patients With Advanced Pancreatic Cancer

Clinical Trial Summary

The purpose of this study is to evaluate the efficacy of oncolytic virus plus PD-1 inhibitor to Patients with Advanced Pancreatic Cancer.

Clinical Trial Description

Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy with a 5-year survival less than 10%. Approximately 80% of patients with pancreatic cancer are diagnosed at an advanced stage. Chemotherapy is one of the major treatments for advanced pancreatic cancer. In 2011, the PRODIGE trial has shown that oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) was associated with a survival advantage but had increased toxicity. Recent studies have suggested that local destruction of tumor tissue by oncolytic virus induced activation and maturation of dendritic cells and tumor-specific T cells by cross-presentation of tumor antigens. PD-1 blocking antibody interferes with PD-1 mediated T-cell regulatory signaling. Combination of PD-1 blocking antibody plus oncolytic virus may increase anti-tumor efficacy in pancreatic cancer. The purpose of this study is to evaluate the efficacy of oncolytic virus plus PD-1 inhibitor to patients with advanced pancreatic cancer who are refractory to standard chemotherapy. Progression-free survival (PFS), objective response rate (ORR), overall survival (OS) and disease control rate (DCR) are measured every three weeks. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06196671
Study type Interventional
Source Fudan University
Contact Ying Yang, MD
Phone 86 64175590
Email yangying@fudanpci.org
Status Not yet recruiting
Phase Phase 2
Start date December 1, 2024
Completion date January 1, 2028
View Details
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