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Clinical Trial Summary

To determine the safety and tolerability of adding durvalumab to mFOLFIRINOX prior to surgery in patients with resectable or borderline resectable pancreatic adenocarcinoma.


Clinical Trial Description

Despite curative surgery, pancreatic cancer patients have five-year survival rates of 20%. Adjuvant chemotherapy has improved survival in resected pancreatic cancer patients but only 10-15% are suitable for surgery and 30% of the resected pancreatic cancer patients miss out on adjuvant chemotherapy due to postoperative complications. Neoadjuvant chemotherapy has improved the resection rates in the patients with non-metastatic pancreatic cancer. There is a growing interest to combine chemotherapy with checkpoint inhibitors to improve disease control in the early stage of pancreas cancer. The investigators propose a pilot study to evaluate the feasibility and safety of combining modified FOLFIRINOX (mFOLFIRINOX) with durvalumab (MEDI4736) in patients with resectable or borderline resectable pancreatic adenocarcinoma. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06094140
Study type Interventional
Source Australasian Gastro-Intestinal Trials Group
Contact Laura Carolan
Phone +61 2 7208 2710
Email laura@gicancer.org.au
Status Recruiting
Phase Phase 2
Start date May 20, 2022
Completion date June 2026

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