An Unusual Association Between Pancreatic Cancer and Purtscher-like Retinopathy

Pancreatic Cancer Clinical Trial

Official title:

An Unusual Association Between Pancreatic Cancer and Purtscher-like Retinopathy: Presentation of a Unique Case

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05350384
• Other study ID #: UCatania666
• Status: Completed
• Start date: June 18, 2021
• Est. completion date: November 1, 2021

Study information

• Verified date: April 2022
• Source: University of Catania
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

AN UNUSUAL ASSOCIATION BETWEEN PANCREATIC CANCER AND PURTSCHER-LIKE RETINOPATHY

Description:

Purtscher's retinopathy may cause sudden loss of vision of varying severity, secondary to head or chest injury. Its pathophysiology is unclear. Purtscher's-like retinopathy has more attenuated clinical and objective features and can be associated with many non-neoplastic pathologies.

Otherwise, an association of this kind of retinopathy with malignancies has been described once in the Literature (multiple myeloma). We present a case report on a unique association between pancreatic cancer and Purtscher-type retinopathy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1
• Est. completion date: November 1, 2021
• Est. primary completion date: July 31, 2021
• Accepts healthy volunteers: No
• Gender: Male
• Age group: N/A and older

Eligibility

Inclusion Criteria: NONE -

Exclusion Criteria: NONE

-

Related Conditions & MeSH terms

• Pancreatic Cancer
• Pancreatic Neoplasms
• Retinal Diseases

Intervention

Drug:
• Methylprednisolone
1 g. of methylprednisolone in saline solution 250 cc once a day for 5 days, and one eye drops of Diclofenac per eye 3 times a day for 30 days

Locations

Country	Name	City	State
Italy	Eva Intagliata	Catania

Sponsors (1)

Lead Sponsor	Collaborator
University of Catania

Country where clinical trial is conducted

Italy, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Unusual association between Purtscher-like retinopathy and a malignant disease (pancreatic cancer)	Ocular history and medical history were irrelevant.	at the diagnosis
Other	Therapy	An improvement of the macular edema and of the sight was reported after one-month administrating 1 g. of methylprednisolone in saline solution 250 cc once a day for 5 days, and one eye drops of Diclofenac per eye 3 times a day. The patient was not found fit for surgical treatment of his pancreatic cancer and therefore oncologic palliative medical treatment was performed.	after 1 month from diagnosis
Primary	funduscopic examination	At the funduscopic examination the back of the eye showed large yellow spots and retinal hemorrhages in the superficial retina. In the early stages, fluorescein angiography showed hypofluorescence in the area of the yellow-white patches while the late stages showed hyperfluorescence	at the onset of symptoms
Secondary	abdominal CT-scan	CT scan of the abdomen revealed a large mass in the tail of the pancreas with direct extension to the vessels of splenic hilum and splenic vein thrombosis. A secondary invasion of the gastric wall and left adrenal gland was also demonstrated. Percutaneous needle biopsy was performed and histopathology showed moderate to poorly differentiated mucinous pancreatic adenocarcinoma.	at the onset of symptoms