OH2 Oncolytic Viral Therapy in Pancreatic Cancer

Status Terminated

Clinical Trial Summary

This phase Ib/II study evaluates the safety and efficacy of OH2 in patients with locally advanced/metastatic pancreatic cancer who have failed first-line standard treatment. OH2 is an oncolytic virus developed upon genetic modifications of the herpes simplex virus type 2 strain HG52, allowing the virus to selectively replicate in tumors. Meanwhile, the delivery of the gene encoding human granulocyte macrophage colony-stimulating factor (GM-CSF) may induce a more potent antitumor immune response.

Clinical Trial Description

OH2 injection ≤ 4 mL, administered by intratumoral injection of EUS-FNA, administered on the first day of the first cycle, every 3 weeks thereafter, administered on the 1st day of each cycle ± 3 days, continuous administration does not more than 6 treatment cycles. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04637698
Study type	Interventional
Source	Binhui Biopharmaceutical Co., Ltd.
Contact
Status	Terminated
Phase	Phase 1/Phase 2
Start date	February 2, 2021
Completion date	May 4, 2023

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