Lidocaine Infusion in Pancreatic Cancer

Status Recruiting

Clinical Trial Summary

This study elucidates the effects of the intravenous (IV) lidocaine infusion on the biology of pancreatic circulating tumor cells (CTCs) isolated from patients undergoing robotic pancreatectomy for all types of pancreatic cancer. A prospective randomized controlled double blinded trial design will be used for the proposed study.

Clinical Trial Description

The primary objective of this study is to determine the effect of IV lidocaine infusion on various enzymatic activities and associated pathways in isolated CTCs as well as the number of CTCs during the perioperative period in patients undergoing robotic pancreatectomy for pancreatic cancer. It is expected that by downregulating the pathways by lidocaine might affect the enzymatic activity in those CTCs as well as the number of CTCs in the circulation. A prospective randomized controlled double blinded trial design will be used for the proposed study. Patients undergoing robotic pancreatectomy for pancreatic cancer will be randomized (ratio 1:1) into two groups: one group will receive a 24-h normal saline infusion and the second group will receive a 24-h lidocaine infusion. Blood samples will be collected in different times perioperatively in order to evaluate the objectives of the study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04048278
Study type	Interventional
Source	University of Illinois at Chicago
Contact	Alexandra Barabanova, MS
Phone	(312)996-4020
Email	barabano@uic.edu
Status	Recruiting
Phase	Early Phase 1
Start date	November 8, 2018
Completion date	January 1, 2025

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