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Acquisition of Portal Venous CTCs and Exosomes From Patients With Pancreatic Cancer by EUS — CTCs  

Pancreatic Cancer Clinical Trial

Official title:
Acquisition of Portal Venous Circulating Tumor Cells and Exosomes From Patients With Pancreatic Cancer by Endoscopic Ultrasound: a Prospective Study

Clinical Trial Summary

The investigators are going to explore the diagnostic and prognostic value of circulating tumor cells and exosomes extracted from the portal venous blood obtained with endoscopic ultrasound in pancreatic cancer patients.

Clinical Trial Description

As the prognosis of pancreatic cancer, a kind of malignant tumor, remains poor due to the low diagnostic rate at the early stage, there is still a significant clinical need to determine individualized tumor molecular profiles and personalized risk for recurrence. Circulating tumor cells (CTCs) and exosomes from patients with primary tumors may hold promise in serving as an informative biomarker to address this clinical need. Here in this study, the investigators are going to explore the feasibility and safety of sampling portal venous blood via endoscopic ultrasound (EUS), and detect portal venous CTCs and analyze mRNA markers of exosomes by RNA-seq. The investigators aim to explore the potential molecular mechanisms in tumor microenvironment and mechanisms of drug resistance. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03821909
Study type Observational
Source The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Contact Shu Zhang, PhD
Phone 13770728926
Email zhangshu19900513@126.com
Status Recruiting
Phase
Start date August 1, 2018
Completion date September 2020
View Details
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