Pancreatic Cancer Clinical Trial
Official title:
A Multimodal Approach to Improve Fitness and Surgical Outcomes for Patients Undergoing Pancreatic Resection
This is a pilot study to investigate the effect of prehabilitation on patients undergoing elective surgery for pancreatic disease.
Pancreatic surgery is high risk. The injury associated with surgery causes a stress response,
comprising a variety of hormonal and metabolic effects. Patients undergoing pancreatic
surgery experience one of the largest stress responses. Prehabilitation is the process of
enhancing an individual's fitness, thereby improving tolerance to an upcoming physiological
stress such as surgery. Studies involving prehabilitation have been shown to improve recovery
after surgery and reduce complication rates. There are currently no published reports of
prehabilitation involving patients undergoing pancreatic surgery. This research study will
explore the effect of prehabilitation in these patients.
Patients with pancreatic disease are some of the least fit surgical candidates due to the
disease process. Exercise training can improve physical fitness before elective abdominal
surgery and nutritional supplementation can also influence clinical course via different
mechanisms. Patients with pancreatic disease are often malnourished for several reasons. We
propose a multimodal approach to prehabilitation involving dietary and exercise interventions
during a four-week period preceding elective surgery. Core data will be collected from
cardiopulmonary exercise tests and blood tests (to assess insulin sensitivity), before and
after prehabilitation. Secondary outcomes such as length of stay and complications will also
be measured postoperatively.
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