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A Study Using 18F-FAZA and PET Scans to Study Hypoxia in Pancreatic Cancer

Pancreatic Cancer Clinical Trial

Official title:
The Evaluation of Hypoxia Imaging in Patients With Pancreatic Cancer Using Positron Emission Tomography (PET) With 18F-Fluoroazomycin Arabinoside (18F-FAZA)

Clinical Trial Summary

This is a diagnostic study to look for low levels of oxygen (hypoxia) in pancreatic cancer using an imaging test called positron emission tomography (PET). Hypoxia can influence how pancreatic cancer grows and responds to treatments such as chemotherapy and radiotherapy. The use of PET scans to measure hypoxia may be better and simpler than the approaches used previously. This study will assess whether or not PET scans using a tracer called 18F-FAZA (18F-Fluoroazomycin Arabinoside) can provide useful information about hypoxia in pancreatic cancer. Also as part of the study, a blood sample will be taken to study biomarkers (substances in the body that may be important indicators of hypoxia and/or pancreatic cancer) that may be useful in studying pancreatic cancer and hypoxia.

Clinical Trial Description

This is a single centre, single arm hypoxia study of pancreatic cancer with PET FAZA imaging. PET-CT imaging of tumor hypoxia with FAZA will be done prior to the start of standard treatment for pancreatic cancer with chemotherapy. The FAZA PET-CT imaging session will last approximately 2.5 hours and include an initial dynamic scan to completely characterize the initial rapid phase of FAZA uptake, followed by a later static scan. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01542177
Study type Observational
Source University Health Network, Toronto
Contact
Status Completed
Phase
Start date February 2012
Completion date September 2019
View Details
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