A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands

Status Active, not recruiting

Clinical Trial Summary

The primary purpose of this study is to find the recommended dose of LGK974 as a single agent and in combination with PDR001 that can be safely given to adult patients with selected solid malignancies that have progressed despite standard therapy or for which no effective standard therapy exists

Clinical Trial Description

This open-label multicenter phase 1 dose escalation study will be the first to administer LGK974 as a single agent or in combination with PDR001 in humans. The study will comprise of 2 parts: a dose escalation of LGK974 as a single agent, followed by a safety expansion in specific disease indications; and a dose escalation of LGK974 in combination with PDR001, followed by a safety expansion in cutaneous melanoma. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01351103
Study type	Interventional
Source	Novartis
Contact
Status	Active, not recruiting
Phase	Phase 1
Start date	December 1, 2011
Completion date	June 18, 2024

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