Pancreatic Cancer Clinical Trial
Official title:
Chemoradiation With Gemcitabine in Combination With Panitumumab for Patients With Locally Advanced Pancreatic Cancer
The purpose of this study is to investigate whether the addition of panitumumab to radiotherapy plus gemcitabine will increase the number of patients who are alive and progression free at 7 months.
This is a phase I/II, multi-center dose escalation study.
Phase I:
Patients will be enrolled in cohorts of 3 per dose level until the MTD of panitumumab has
been established.
Phase II:
Up to approximately 56 patients will be treated at the MTD level of panitumumab as
established in the phase I part of the study.
Based on the historic data of patients with pancreatic cancer treated with gemcitabine based
chemoradiation, we aim to increase the number of patients who are alive and progression free
at 7 months from the historical value of 50% to 70% with the combination treatment of
chemoradiation plus panitumumab.
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