Pancreatic Cancer Clinical Trial
Official title:
Mitomycin and Ifosfamide (MI) as Salvage Therapy for Metastatic Pancreatic Adenocarcinoma: a Phase II Study.
RATIONALE: Drugs used in chemotherapy, such as mitomycin C and ifosfamide, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving mitomycin C together with
ifosfamide works in treating patients with metastatic pancreatic cancer.
OBJECTIVES:
- To assess the therapeutic activity of a mitomycin C and ifosfamide combination, in
terms of progression-free survival rate at 6 months, in patients with metastatic stage
IV adenocarcinoma of the pancreas.
OUTLINE: Patients receive mitomycin C IV on day 1 and ifosfamide IV on days 1-3. Courses
repeat every 4 weeks for up to 6 courses in the absence of disease progression or
unacceptable toxicity.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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