Pancreatic Cancer Clinical Trial
Official title:
A Phase I/II Study of Chemoradiation With Oxaliplatin and 5FU for Locally Advanced Pancreatic Cancer
The intention of this trial is to determine the maximum tolerated of the treatment combination and to evaluate its safety and efficacy.
Previous studies have demonstrated that neoadjuvant chemoradiation can lead to improved
survival with a portion of patients proceeding to resection. This trial will incorporate a
similar trial structure using newer agents in patients who present with locally advanced
unresectable pancreatic cancer. Specifically oxaliplatin will be used owing to its greater
activity in comparison to cisplatin and favorable therapeutic index in combination with
radiation compared to gemcitabine.
In summary, the primary outcome measure of the phase I portion of the trial is to determine
the maximum tolerated dose of this combination. Following the determination of this dose, the
phase II portion of the trial will characterize the toxicity of this regimen as well as
evaluate for long-term efficacy.
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