Pancreatic Cancer Clinical Trial
Official title:
Phase II Trial Of Perifosine In Locally Advanced, Unresectable Or Metastatic Pancreatic Adenocarcinoma
RATIONALE: Perifosine may stop the growth of tumor cells by blocking the enzymes necessary
for tumor cell growth.
PURPOSE: Phase II trial to study the effectiveness of perifosine in treating patients who
have locally advanced, unresectable, or metastatic pancreatic cancer.
OBJECTIVES:
- Determine the activity of perifosine, in terms of objective response, in patients with
locally advanced, unresectable, or metastatic pancreatic cancer.
- Determine the response duration, progression-free survival, and overall survival of
patients treated with this drug.
- Determine the toxicity of this drug in these patients.
OUTLINE: This is a multicenter study.
Patients receive oral perifosine every 6 hours for a total of 6 doses and then once daily in
the absence of disease progression or unacceptable toxicity.
Patients are followed every 3 months for 3 years.
PROJECTED ACCRUAL: A total of 35-84 patients will be accrued for this study within 21
months.
;
Masking: Open Label, Primary Purpose: Treatment
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