Pancreatic Cancer Clinical Trial
Official title:
Phase I Study: Electroporation Therapy With Bleomycin For The Treatment Of Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Electroporation therapy may enhance the ability of chemotherapy
drugs to enter tumor cells. Combining chemotherapy with electroporation therapy may kill
more tumor cells.
PURPOSE: Phase I trial to study the effectiveness of electroporation therapy and bleomycin
in treating patients who have locally advanced pancreatic cancer.
OBJECTIVES: I. Determine the safety and surgical feasibility of electroporation therapy with
bleomycin in patients with locally advanced pancreatic cancer. II. Determine the overall and
progression-free survival of patients treated with this regimen.
OUTLINE: Patients receive bleomycin intratumorally during laparotomy. Approximately 15
minutes after the intratumoral injection, patients receive bleomycin IV over 10 minutes.
Approximately 5 minutes after the IV injection, patients undergo electroporation therapy
comprising electrical pulses directly to the pancreas and surrounding tissues. Patients are
followed weekly for 4-6 weeks and then every 2 months thereafter.
PROJECTED ACCRUAL: A total of 15 patients will be accrued for this study within 12-18
months.
;
Primary Purpose: Treatment
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